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The safe and effective use of medications in the newborn intensive care unit (NICU) requires an understanding of the principles of pharmacokinetics (PK) and pharmacodynamics (PD) that guide individual dosing and aim to provide drug exposures designed for the best…
Effective antimicrobial treatment typically begins with empirical therapy at a dose that is most likely to cure the infection with the minimal risk of toxic effects. To select the correct dosage, clinicians need to understand and apply the principles of…