Between 1953 and 1956, a strong association between donor leukocyte chimerism and acquired donor-specific tolerance was demonstrated in studies of mouse models. Bone marrow transplantation a dozen years later in immune-deficient and cytoablated human recipients was a logical extension. In…
Videos 20.1 Intestinal Graft Procurement 20.2 Multivisceral Transplantation Introduction All different types of visceral organ transplants containing small bowel can be categorized into three main prototypes: isolated intestinal, liver-intestinal, and multivisceral transplantations. The proper understanding of vascular anatomy is necessary…
Introduction The successful clinical introduction of intestinal and multivisceral transplantation in the 1990s fueled a great interest in the management of patients with short gut syndrome (SGS) and gastrointestinal failure. With the early restricted utilization of transplantation as a rescue…
Continuous progress has been made over the last few decades in the management of children with intestinal failure. Significant advances include gut rehabilitation, autologous reconstruction, bowel lengthening, and visceral transplantation. Gut replacement is one of the most important milestones in…