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Abstract Background The introduction of monoclonal antibody drugs has had major impact in medicine, leading to extraordinary progress in the treatment of a wide variety of diseases, particularly malignancies and chronic inflammatory and autoimmune diseases. Content This chapter provides a…
Key Points The major histocompatibility complex (MHC) genomic region contains many genes with immune-related functions, including the human leukocyte antigen (HLA) genes. Identification of genes within the MHC has increased the possibility of defining the genetic basis of immunity. The…