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Introduction This chapter is designed to be a broad overview of selected systemic therapies for dermatologic diseases. It provides an historical perspective for each drug, a discussion of its mechanism of action and side effects, and touches briefly on indications…

Key Points Skin manifestations of chronic kidney disease (CKD) are commonly encountered and can be due to (1) the cause of the underlying renal disease, either acquired or heritable; (2) conditions unique to uremia; or (3) immunosuppressive therapies and/or immunosuppression…