Hypoxic-ischemic encephalopathy (HIE) in the perinatal period represents an important portion of neonatal neurology. To understand the features of HIE, which are discussed extensively in this unit, it is necessary to be cognizant of the physiological and biochemical derangements that…
KEY POINTS 1. A healthy fetus has considerable aerobic and anaerobic reserves to successfully adapt to transient or mild hypoxia. Prolonged or repeated severe asphyxia results in failure of adaptation and progressive hypotension and hypoperfusion. The severity of brain injury…
Acknowledgments Our work reported in this chapter is supported by the Health Research Council of New Zealand, the National Institutes of Health, the Lottery Health Board of New Zealand, the Auckland Medical Research Foundation, and the Neurological Foundation of New…