General information Indapamide is a thiazide-like diuretic. Although it was introduced as a specific antihypertensive drug without appreciable diuretic action, the effects of indapamide are no different from those of bendroflumethiazide. Organs and systems Cardiovascular Indapamide has been associated with…
General information Indanediones have the same mechanism of action as the coumarins. However, they are generally more toxic than the coumarins, and can cause allergic reactions capable of involving many organs and sometimes resulting in death [ ]. These reactions…
See also Antivenoms , Hymenoptera venoms General information Desensitization is used in the treatment of IgE-mediated disease. Increasing doses of an allergen are injected subcutaneously over a varying time span. The aim of the treatment is to decrease sensitivity to…
General information Immunoglobulin preparations are concentrated protein solutions derived from pooled plasma from adults or animals. They contain specific antibodies in proportion to the infectious and immunization experience of the population from whose plasma they are prepared [ ]. Large…
General information Imiquimod is an immune response enhancer that induces production of interferon and several other cytokines. It is used, in formulations containing 5%, to treat external genital and perianal warts/condylomata acuminata in adults [ ]. As imiquimod-treated warts regress,…
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See also Angiotensin-converting enzyme inhibitors General information Imidapril is a long-acting, non-sulfhydryl ACE inhibitor that has been used in patients with hypertension, congestive heart failure, acute myocardial infarction, and diabetic nephropathy. It is a prodrug, rapidly converted in the liver…
General information Imatinib (STI571), an inhibitor of bcr-abl tyrosine kinase, has become the first-line agent in the treatment of the chronic phase of chronic myeloid leukemia and of locally advanced and metastatic gastrointestinal stromal tumors (GISTs) that express the CD117…
General information Iloprost is an analogue of prostacyclin (PGI 2 ), the pharmacodynamic properties of which it mimics, namely inhibition of platelet aggregation, vasodilatation, and cytoprotection. Iloprost has greater chemical stability than prostacyclin, which facilitates its clinical use [ ].…
General information The family of Illiciaceae contains a single genus, Illicium , the star anise species. Illicium species Illicium anisatum contains sesquiterpenoids, such as anisatin, anisotin, neoanisatin, and pseudoanisatin. Illicium religiosum (Japanese star anise) contains shikimic acid, anisatin and neoanisatin.…