Key features ▪ The major determinant of normal skin color is the activity of melanocytes, i.e. the quantity and quality of pigment production, not the density of melanocytes ▪ Melanocytes contain a unique intracytoplasmic organelle, the melanosome, which is the…
Key Points Skin infections occur at a great frequency in solid organ and bone marrow transplant recipients largely as a consequence of immunosuppression. Neoplasms, particularly squamous cell carcinomas, occur at greater frequency, are more difficult to manage, and are more…
Key Points A variety of vascular lesions can serve as cutaneous signs of systemic disease. Telangiectasias or angiokeratomas with particular morphologies and distributions raise suspicion for an autoimmune connective tissue disease or a genetic disorder. Vascular anomalies are divided into…
Key Points The major determinant of human skin color and sensitivity to ultraviolet radiation (UVR) is the activity of melanocytes, i.e. the quantity and quality of pigment production, not the density of melanocytes. Melanocytes contain a unique lysosome-related intracytoplasmic organelle,…