Antiphospholipid (aPL) syndrome (APS) is an autoimmune thrombophilic syndrome for which definitive disease mechanisms have not been established. The condition is defined and diagnosed by a constellation of clinical and laboratory criteria, detailed below. This chapter reviews the current understanding…
Antiphospholipid (aPL) syndrome (APS) is an autoimmune thrombophilic syndrome for which definitive disease mechanisms have not been established. The condition is defined and diagnosed by a constellation of clinical and laboratory criteria, detailed below. This chapter reviews the current understanding…
Key Points Several regulatory mechanisms have evolved to limit the extent of clot formation after coagulation is triggered. Under normal conditions, these allow hemostasis to be achieved while preventing the growth of a hemostatic plug into an intravascular thrombus. Among…