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Introduction Many systemic diseases are associated with lung or pleural injury, either as a component of the disease itself or as a consequence of other types of injury induced by the disease or its treatment. This chapter focuses on systemic…

Introduction The mononuclear phagocyte system includes monocytes, macrophages/histiocytes, and dendritic cells. Macrophages/histiocytes are tissue-based cells that have an important phagocytic function and produce a variety of bioactive substances that play roles in inflammation and fibrosis. Alveolar macrophages are a normal…