Tag Gordon F. Tomaselli

Autonomic and Oxidant Regulation of Cardiac Sodium Currents: Mechanisms and Consequences

Introduction Posttranslational modification of ion channels and related proteins is an important determinant of transcription, splicing, functional expression, localization, and macromolecular assembly. Ion channels and their modifications are important in virtually all physiologic processes and in the heart and vasculature…

Atrial Fibrillation: Clinical Features, Mechanisms, and Management

Additional content is available online at Elsevier eBooks for Practicing Clinicians Electrocardiographic Features Atrial fibrillation (AF) is a supraventricular arrhythmia characterized electrocardiographically by low-amplitude baseline oscillations (fibrillatory or f waves from the fibrillating atria) and an irregularly irregular ventricular rhythm.…