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Central concept figure: comprehensive medical device pathology Introduction The last several decades have witnessed a virtual explosion in the armamentarium of interventional and surgical procedures and medical devices available to manage cardiovascular diseases. For example, percutaneous treatment of coronary artery…

Open full size image With a worldwide prevalence of over 100 million cases, valvular heart disease remains a significant human and clinical burden, necessitating over an estimated 400,000 interventions annually worldwide and estimated to surpass 850,000 by 2050 . Three…