Frank Lehmann-Horn Archives

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Malignant Hyperthermia : An Inherited Disorder of Muscle Calcium Metabolism

Malignant Hyperthermia—Deaths in General Anesthesia The name malignant hyperthermia (MH) is derived from the clinical observations of Denborough and Lovell, who analyzed the unexplained deaths of previously asymptomatic patients undergoing general anesthesia in 1960. These patients exhibited symptoms of muscle…

Muscle Channelopathies : Myotonias and Periodic Paralyses

Introduction Defective ion channels may play a causal role in disease pathogenesis. This implication was first concluded from the observation of an abnormal ion conductance in muscle fibers biopsied from myotonic goats. In humans, a similar conclusion was reached for…