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Summary of Key Points A clinically relevant pathologic classification of lung cancer is essential for accurate diagnosis and for patients to receive appropriate therapy. Although classification of the majority of lung cancers is straightforward, areas of controversy and diagnostic challenges…

Introduction Neuroendocrine neoplasms include a spectrum of malignant neoplasms ranging from relatively low- to intermediate-grade malignancies (typical and atypical carcinoid [AC] tumors) to high-grade malignancies (small cell carcinoma, large cell neuroendocrine carcinoma) and are among the most aggressive primary lung…