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Most endocrine disorders are due to either an excess or a deficiency of a hormone that is transported in the systemic circulation and therefore result in multiorgan manifestations. Since individual hormones commonly have multiple sites of action, patients rarely present…

Endocrine system diseases generally affect multiple organ systems, because hormones secreted into the general circulation act on multiple tissues that are distant from their sources of synthesis and secretion. Nearly all hormones and accompanying hormonal disorders may be associated with…