David A. Solomon MD PhD Archives

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The nervous system is affected in many familial tumor or “cancer predisposition” syndromes. The genetic and clinicopathologic features are summarized in Table 22.1 . Autosomal dominant inheritance is most common, and the majority of these disorders result from inactivation of…

Integrating Molecular Diagnostics With Surgical Neuropathology

Human disease is increasingly appreciated to have an underlying genetic basis. This is particularly true of neurologic disease, where genetic variants have been shown to increase risk or directly cause schizophrenia, autism spectrum disorder, and neurodegenerative diseases including Alzheimer disease,…

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Familial Tumor Syndromes

Integrating Molecular Diagnostics With Surgical Neuropathology