Introduction Many systemic diseases are associated with lung or pleural injury, either as a component of the disease itself or as a consequence of other types of injury induced by the disease or its treatment. This chapter focuses on systemic…
Introduction The mononuclear phagocyte system includes monocytes, macrophages/histiocytes, and dendritic cells. Macrophages/histiocytes are tissue-based cells that have an important phagocytic function and produce a variety of bioactive substances that play roles in inflammation and fibrosis. Alveolar macrophages are a normal…
Introduction Drug-induced lung injury is common and can be induced by a wide variety of drugs used for treatment of many different clinical conditions. More than 600 prescribed medications have been reported to cause drug-induced pulmonary toxicity. Adverse drug reactions…
Hypersensitivity Pneumonitis Hypersensitivity Pneumonitis—Fact Sheet Definition ▪ Diffuse interstitial granulomatous pneumonitis, caused by exposure to inhaled organic antigens or other particles of small size in susceptible individuals ▪ Large number of syndromes associated with specific triggering agents; major categories of…