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Introduction Individuals vary widely in their responses to therapy with most drugs. Indeed, response to cardiovascular drug therapy, and antiarrhythmics in particular, is so highly variable that studying the underlying mechanisms has elucidated important lessons for understanding variable responses to…

Additional content is available online at Elsevier eBooks for Practicing Clinicians In 2018 the total cost of health care in the United States was approximately $3.6 trillion, 17.7% of the Gross Domestic Product, and more than 10% was spent on…