Tag Charles B. Berde

Acute Pain

the practice of pain management in children continues to advance. Since the early 1980s, clinicians have recognized that neonates and infants experience pain and process those learning experiences. Research has demonstrated long-term adverse consequences of unrelieved pain, including harmful neuroendocrine…

Local Anesthetics

Local anesthesia can be defined as loss of sensation in a discrete region of the body caused by disruption of nerve impulse generation or propagation. Local anesthesia can be produced by various chemical and physical means. However, in routine clinical…

Local Anesthetics

Key Points ▪ Local anesthetics block voltage-gated sodium channels and thereby interrupt initiation and propagation of impulses in axons, but they have a wide variety of other biologic actions, desirable and undesirable. ▪ Currently available local anesthetics are of two…