Between 1953 and 1956, a strong association between donor leukocyte chimerism and acquired donor-specific tolerance was demonstrated in studies of mouse models. Bone marrow transplantation a dozen years later in immune-deficient and cytoablated human recipients was a logical extension. In…
Liver transplantation is used to treat a broad spectrum of end-stage liver diseases. Hepatitis C virus (HCV) and alcoholic and nonalcoholic fatty liver disease–induced cirrhosis are the leading indications in North America, Europe, and South America, whereas in Asia, hepatitis…
Introduction Liver transplantation is used worldwide to treat a broad spectrum of end-stage liver diseases. Nonalcoholic fatty liver disease–induced cirrhosis, alcohol-induced liver disease, and hepatitis C virus (HCV) infection are the leading indications in North America, Europe, and South America.…