The amyloidoses are protein-misfolding diseases caused by a precursor protein that undergoes a conformational change, which in turn triggers the formation of amyloid fibrils that damage different organs. Amyloidosis can be either localized or systemic. In systemic amyloidosis ( Table…
Summary of Key Points Multiple Myeloma Multiple myeloma accounts for approximately 10% of hematologic malignancies. Approximately 30,000 new cases are estimated to occur each year in the United States. In almost all patients, multiple myeloma is thought to evolve from…
Unlike solid tumors, myeloma staging is a composite score based on the four tests: blood albumin, beta-2 microglobulin, lactate dehydrogenate (LDH), and bone marrow Fluorescent in situ hybridization (FISH). Stage I is albumin 3.5 g/dL or greater, beta-2 microglobulin is…