Superficially Invasive Squamous Cell Carcinoma


D efinition —Early invasive squamous cell carcinoma (SCC) measuring no more than 3 mm in depth in the biopsy or conization specimen.

Clinical Features

Epidemiology

  • Associated with high-risk human papillomavirus (HPV) infection and preexisting cervical intraepithelial neoplasia.

  • Will be found in approximately 1 : 200 cone biopsies of high-grade squamous intraepithelial lesion (HSIL).

  • Can be found at any age; median age around 35 to 40 years.

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