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Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis presenting as pustules enlarging and ulcerating with violaceous, necrotic, and undermined borders healing with cribriform scarring. Multiple subtypes exist involving any skin location. PG has several associations ( Table 212.1 ) that should be considered in the workup.
Associated conditions (most to least common) |
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Hematologic disease (leukemia, lymphoma, myelodysplasia, myelofibrosis, monoclonal gammopathy of undetermined significance, polycythemia vera, IgA gammopathy) |
IBD (ulcerative colitis, Crohn disease) |
Other inflammatory diseases and syndromes (rheumatoid arthritis; Sjögren syndrome; systemic lupus erythematosus; granulomatosis with polyangiitis; pyogenic arthritis, hidradenitis suppurativa [PASH]; pyogenic arthritis, pyoderma gangrenosum, acne [PAPA]) |
Solid organ malignancy |
Infectious (hepatitis B/C, human immunodeficiency virus) |
Hidradenitis suppurativa |
Pregnancy |
Leukocyte adherence deficiency |
Endocrine disorders (i.e., metabolic syndrome) |
Goals of PG treatment include pain control, superinfection prevention, and facilitating healing. Pain is managed with oral acetaminophen, non-steroidal antiinflammatory drugs, opioids, gabapentin, pregabalin, and nortriptyline. Medical and surgical management should be combined with maintaining a moist wound environment with foam or hydrocolloid dressings. Consider conservative debridement, keeping in mind the risk of pathergy.
No treatment is consistently effective for PG . Conservative therapy with wound care and topical corticosteroids or calcineurin inhibitors are reasonable first-line options for small areas of slowly progressive PG. However, if PG is rapidly progressive, systemic therapies like systemic corticosteroids (sCS) or ciclosporin should be initiated early.
sCS are often first-line therapies in conjunction with topical care. Response to sCS is also a diagnostic feature of PG. If PG is associated with a systemic disorder, treating the underlying disorder may improve PG. Suggested investigations for working up PG are listed in Specific Investigations. When active inflammation is evident, therapy should be continued; however, if inflammation subsides, immunomodulatory therapy is discontinued while wound care continues. This is often called ‘Gulliver Sign’ (Landis ET, Taheri A, Jorizzo JL. Gulliver’s sign: a recognizable transition from inflammatory to healing stages of pyoderma gangrenosum. J Dermatolog Treat. 2015;26(2):171–172).
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Abdul-Fattah B, Al-Muriesh M, Huang CZ. Dermatol Ther 2018; 31(5): e12697.
Napolitano M, Megna M, Patrì A, et al. G Ital Dermatol Venereol 2019; 154(3): 361–3.
Case report of female with refractory Crohn disease and parastomal PG with PG responding to topical tacrolimus 0.1% ointment BID.
Caution: a case of systemic absorption and acute nephrotoxicity has been reported in a patient who applied 60 g of tacrolimus ointment (i.e., presumably 60 g of 0.1% ointment) daily to PG .
Abdelrahman W, Walsh MY, Hoey SE, et al. Case Rep Pediatr 2016; 2016: 5971706.
Dramatic improvement of pediatric PG with clobetasol ointment within 24 hours.
Chriba M, Skellett AM, Levell NJ. Clin Exp Dermatol 2010; 35: 337–8.
A case of peristomal PG healed over 4 weeks using beclomethasone dipropionate 200 mcg, four puffs daily.
Din RS, Tsiaras WG, Li DG, et al. J Drugs Dermatol 2018; 17(10): 1058–60.
The authors reviewed 27 patients with PG treated with dapsone with the most common peak dosage at 50 mg or 100 mg daily. The average time to initial treatment response was 5.3 weeks. The average duration of treatment was 14.3 months.
Low cost and familiarity of dermatologists with dapsone probably contribute to its popularity. Dapsone is often used in combination with other modalities, especially sCS.
Schoch JJ, Tolkachjov SN, Cappel JA, et al. Pediatr Dermatol 2017; 34(1): 39–45.
Retrospective review of 13 children with PG. Sulfasalazine or related 5-aminosalicylate drugs were used in 46% of patients, four of whom had complete response (CR) while two had a partial response.
Gardner LW, Acker DW. Arch Dermatol 1972; 106: 599–600.
A case of multifocal PG responded to intralesional triamcinolone acetonide 10 mg/mL. Doses ranging from 40 mg to 200 mg were injected at any one time.
Berth-Jones J, Tan SV, Graham-Brown RAC, et al. J Dermatol Treat 1989; 1: 23–5.
Seven cases improved on minocycline dosed at 100 mg BID or 200 mg BID.
Garg S, Arora D, Singh K, et al. Clin Dermatol Rev 2018; 2: 41–2.
Case report of PG treated with dapsone 100 mg daily and doxycycline 100 mg BID with complete healing.
Patel GK, Rhodes JR, Evans B, et al. J Dermatol Treat 2004; 15: 122–5.
Two cases responded to nicotine in Cetomacrogol cream.
Bellini V, Simonetti S, Lisi P. J Eur Acad Dermatol Venereol 2008; 22: 113–5.
A patient demonstrated clearance of PG within 8 weeks of using pimecrolimus cream BID.
De Cock KM, Thorne MG. Br J Dermatol 1980; 102: 231–3.
Two cases responded to sodium cromoglycate aqueous solution (2% weight/volume Rynacrom nasal spray).
Safe treatment. Solutions have been applied to lesions in concentrations from 1% to 4%. The solution can be sprayed onto the ulcer or applied on gauze or under occlusion with a hydrocolloid dressing. This drug may act by inhibiting neutrophil migration or cytotoxicity .
Join-Lambert O, Duchatelet S, Delage M, et al. J Am Acad Dermatol 2015; 73(5 Suppl 1): S66–9.
Four cases of PASH treated with intravenous ceftriaxone and oral metronidazole or intravenous ertapenem for 3–6 weeks, followed by oral therapy combining 2–3 antibiotics (rifampin, moxifloxacin, metronidazole, amoxicillin, and/or linezolid) given in 4–6-week cycles.
Ormerod AD, Thomas KS, Craig FE, et al. BMJ 2015; 350: h2956.
In this study with 112 randomized patients, prednisolone 0.75 mg/kg/day was compared with ciclosporin 4 mg/kg/day to a maximum dose of 75 and 400 mg/day, respectively. The treatments did not differ across a range of objective and patient-reported outcomes. At 6 months, 47% of ulcers healed in each group. Infections were more common serious adverse events in the group receiving prednisolone.
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Brooklyn TN, Dunnill MG, Shetty A, et al. Gut 2006; 55: 505–9.
Tan MH, Gordon M, Lebwohl O, et al. Arch Dermatol 2001; 137: 930–3.
Numerous case reports further established response to infliximab.
McGowan JW 4th, Johnson CA, Lynn A. J Drugs Dermatol 2004; 3: 441–4.
The first of several cases reported to respond to etanercept 25–50 mg twice weekly.
Pomerantz RG, Husni ME, Mody E, et al. Br J Dermatol 2007; 157: 1274–5.
Improvement occurred in a case that failed etanercept.
Conventional dosing regimens: 40–80 mg every 2 weeks with and without an initial loading dose of 80 mg.
Diotallevi F, Campanati A, Radi G, et al. Dermatol Ther 2019; 32(4): e12928.
Case of ulcerative rectocolitis and PG treated with golimumab, improving both.
Newell LM, Malkinson FD. Arch Dermatol 1983; 119: 495–7.
A refractory case of PG responded to cyclophosphamide 150 mg daily.
Zonana-Nacach A, Jimenez-Balderas FJ, Martinez-Osuna P, et al. J Rheumatol 1994; 21: 1352–6.
Two patients improved on pulsed intravenous cyclophosphamide at doses of 500 mg/m 2 combined with oral corticosteroid. In both cases, CR was subsequently maintained using oral cyclophosphamide 100 mg daily.
Burruss JB, Farmer ER, Callen JP. J Am Acad Dermatol 1996; 35: 720–4.
Chlorambucil, 2–4 mg daily, was successfully used in six cases, both alone and in combination with sCS.
Tsele E, Yu RCH, Chu AC. Clin Exp Dermatol 1992; 17: 437–40.
The application of nitrogen mustard 20 mg/100 mL in aqueous solution on gauze swabs proved helpful in a treatment-resistant case associated with immunoglobulin A (IgA) paraproteinemia.
Fujimoto E, Fujimoto N, Kuroda K, et al. Br J Dermatol 2004; 151: 1090–2.
Seishima M, Mizutani Y, Shibuya Y, et al. Ther Apher Dial 2007; 11: 177–82.
Three patients improved after weekly treatments for 10 or 11 weeks.
Song H, Lahood N, Mostaghimi A. Br J Dermatol 2018; 178(2): 363–8.
Case series of 49 patients with PG treated with IVIG with CR or partial response (PR) noted in 43 and CR in 26.
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