Pyloric Stenosis

Incidence: 1:300-1000 live births.

Incidence is 3–5% higher among children of affected parents.

More common in males.

Similar to other abd procedures in pts of same age.

Some association with GU anomalies.

Some pts have elevated unconjugated bilirubin related to decreased glucuronyl transferase activity; this returns to normal after correction of stenosis.

Full stomach. Recurrent emesis leads to dehydration, electrolyte imbalance, and alkalosis.

Typically pts have hypochloremic, hyperkalemic metabolic alkalosis.

Metabolic acidosis found in the most severe cases.

Reduced size of gastric outlet impedes emptying of contents, which can cause abnormal nutrition, gastric distention, repeated vomiting, and dehydration.

Onset of symptoms occurs at 3–6 wk of age.

Usually surgically cured.

Almost exclusively genetic in infants

Can be acquired in adults