Prothrombin complex concentrate

General information

Prothrombin complex products contain constant amounts of clotting factors II, VII, IX, and X, bypassing the need for factor VIII in the clotting cascade. They are used to reverse the effects of oral anticoagulants (for example during surgery or bleeding episodes) [ ] and to treat bleeding episodes in hemophiliacs with inhibitors of factor VIII [ ]. Prothrombin complex achieves more rapid and effective reversal of acquired coagulation defects than fresh frozen plasma. However, a potential disadvantage is the risk of thromboembolism.

Organs and systems