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Probucol
General information
Probucol is a lipid-modifying drug that is stored in fat, from which it is slowly released; it can still be detected in plasma 6 months after the end of treatment.
Adverse reactions to probucol have been reviewed [ ].
Drug studies
Observational studies
A series of 30 patients was given probucol for 60 days; adverse reactions were reported in five subjects, four of them having dizziness and two nausea and flatulence; the symptoms gradually disappeared without the need for a change in dosage [ ].
Placebo-controlled studies
The Probucol Quantitative Regression Swedish Trial (PQRST) showed no improvement in lumen volume of the femoral artery in patients given probucol plus colestyramine, compared with those given colestyramine alone, and doubts were raised about its efficacy [ ].
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