Prehospital Assessment and Systems of Care


Case Vignette

A 56-year-old riverboat captain experienced sudden onset of shortness of breath and diaphoresis at 1:30 am while on his boat near Red Wing, Minnesota ( Figure 5-e1 ). Emergency Medical Services (EMS) were activated from the boat, and at 2:26 am , the first responders from the Red Wing Fire Department arrived on scene. At 2:38 am , a 12-lead electrocardiogram (ECG) ( Figure 5-e2 ) was obtained showing a large inferior-posterior ST-elevation consistent with ST-elevation myocardial infarction (STEMI). By 3:09 am , a helicopter arrived to transport the patient to the Minneapolis Heart Institute Regional STEMI Center 55 miles away, in Minneapolis, Minnesota. The patient was loaded in the helicopter at 3:20 am ; treated with aspirin 325 mg, clopidogrel 600 mg, and a weight-based intravenous bolus of unfractionated heparin; and arrived at the STEMI center at 3:38 am . He underwent emergent cardiac catheterization, which revealed a 100% thrombotic occlusion of the mid-right coronary artery ( Figures 5-e3A and 5-e3B ) and had a successful primary percutaneous coronary intervention (PPCI). Post-PPCI, his left ventricular ejection fraction was 65% with mild hypokinesis of the inferior wall. The prehospital ECG-to-device time was 101 minutes, and the door-to-device time was 41 minutes. He was discharged from the hospital the following day and was asymptomatic at 1-year follow-up.

In summary, a 56-year-old with acute onset of shortness of breath in the middle of the night, in the middle of the Minneapolis River, 55 miles from the nearest PPCI center, was able to receive guideline-directed medical therapy and PPCI in a timely fashion with an excellent outcome, as a result of a regionalized STEMI system with prespecified standardized protocols and transfer agreements in place.

Introduction

Nearly 500,000 Americans experience an acute STEMI each year in the United States (see Chapter 2 ). A decade ago, many of these patients did not receive appropriate treatment for this life-threatening condition. Approximately 30% of STEMI patients did not receive any form of reperfusion therapy (PPCI or fibrinolysis). Of those who underwent PPCI, only 40% were treated within the recommended time frame (medical contact-to-device time ≤90 minutes). For patients who received fibrinolytics, less than 50% met the recommended door-to-needle time of ≤30 minutes. Care for STEMI patients has evolved dramatically over the past 30 years (see Chapter 13 ). The 1990s was a period of rapid evolution in STEMI care, from fibrinolytics to coronary angiography with balloon angioplasty, and subsequently, coronary stenting. However, it was not until the past decade that the systems for delivery of care became a focus of attention.

FIGURE 5-e1, Minnesota map with arrows for Red Wing-Mississippi River Lock and Dam and for Minneapolis Heart Institute.

FIGURE 5-e2, Twelve-lead electrocardiogram demonstrating a large inferior-posterior ST-elevation myocardial infarction.

FIGURE 5-e3, (A) Selective right coronary angiography demonstrating a 100% thrombotic occlusion in the right coronary artery upon arrival to the primary percutaneous coronary intervention (PPCI) hospital. (B) After aspiration thrombectomy and placement of a stent in the right coronary artery.

Regional STEMI systems of care have drastically changed the approach to health care delivery for acute coronary syndromes (ACS), providing access to PPCI for an increasing proportion of the population. This evolution has resulted in dramatic improvements in time to treatment ( Figure 5-1 ) and cardiovascular outcomes ( Figure 5-2 ). Chapter 13 provides an overview of the principles of care for acute MI, including the critical relationship between time to treatment and outcomes in STEMI (see Figure 13-3 ). Selection among the approaches to reperfusion therapy is addressed in Chapter 14 . Treatment with fibrinolytic therapy is discussed in Chapter 15 , and PPCI is discussed in Chapter 17 . In this chapter, we describe the design and implementation of complex regional systems of care and examine the individual components of any successful STEMI system of care that include: (1) rapid and thorough prehospital evaluation and triage, typically performed by EMS; (2) referring hospitals and clinics (“referral centers”); and (3) regional, tertiary care receiving centers capable of PPCI, preferably with surgical backup (“receiving centers”) ( Figure 5-3 ).

FIGURE 5-1, Trends in door-to-balloon (D2B) time among U.S. hospitals (2005 to 2010) showing marked improvement in the percentage of patients with D2B time of less than 90 minutes.

FIGURE 5-2, Trends in U.S. ST-elevation myocardial infarction (STEMI) care from 2003 to 2011. Use of primary PCI increased to 80% with decreasing mortality.

FIGURE 5-3, Components of a successful system-of-care for ST-elevation myocardial infarction (STEMI).

Although these critical elements of triage, transportation, referral centers, and receiving centers are integral components of a STEMI system, no two STEMI systems are alike. Diversity in geography, politics, and sociodemographics across the United States and throughout the world result in a wide variety of STEMI systems, which are all directed toward the same goal—to increase access to timely reperfusion with PPCI for STEMI by reducing delays inherent in systems of care (see also Chapter 13 and Figure 14-1 ). In the United States, current American College of Cardiology Foundation (ACCF)/American Heart Association (AHA) guidelines (see Figure 13-5 ) recommend EMS transportation of STEMI patients directly to a receiving center hospital for PPCI, with an ideal first medical contact to PPCI device (FMC-to-balloon) time goal of less than 90 minutes (class I, level of evidence B). Furthermore, for patients presenting to a non–PPCI-capable hospital, immediate transfer to a receiving center hospital for PPCI is the recommend reperfusion strategy with a goal FMC-to-device time of less than 120 minutes (class I, level of evidence B).

Prehospital Evaluation

Evolution of Emergency Medical Services

The first U.S. Civilian ambulance service was formed in 1865 in Cincinnati, Ohio. It was comprised of local hospital interns who drove a horse-drawn carriage ( Figure 5-e4 ). The first “rescue squad,” designed to deliver basic first aid to civilians was formed in the late 1920s in Roanoke, Virginia. However, there were few advances in emergency care services until the late 1960s. In 1966, the National Academy of Sciences published a statement that many deaths in the United States were preventable and could be reduced through community education, safety standards, and prehospital coordination. This recognition, along with advances in the field of cardiopulmonary resuscitation (CPR) and management of out-of-hospital cardiac arrest (OHCA), served as the impetus for the first statewide EMS system in Maryland, thanks in large part to the efforts of R. Adams Cowley. In 1968, St. Vincent’s Hospital in New York City built the nation’s first mobile coronary care unit, staffed initially with physicians and later by paramedics. This unit was the first to evaluate and triage patients with cardiac complaints and included a portable, battery-powered cardiac monitor and defibrillator, as well as supplies for intravenous access, mobile oxygen, and medications. From here, the modern day EMS system was born. Today, EMS providers in the United States care for an estimated 22 million patients per year. The incorporation of various vehicles, including ambulance vans, helicopters, and airplanes, has allowed for rapid mobilization and transportation of patients over great distances in short periods of time.

FIGURE 5-e4, A horse-drawn ambulance at New York City’s Bellevue Hospital, 1869.

With the development of formal EMS systems throughout the country, the framework was in place to build complex regional systems of care for a variety of medical conditions. The first systems of care were designed for trauma patients and acute cardiovascular emergencies, such as STEMI and stroke. The integration of EMS and the incorporation of the prehospital phase for ACS evaluation and diagnosis are integral components of any regionalized STEMI system of care. EMS providers and other first responders have four primary responsibilities: (1) prehospital evaluation, (2) treatment, (3) triage, and (4) transfer ( Figure 5-4 ).

FIGURE 5-4, The four major responsibilities of EMS providers in a regional ST-elevation myocardial infarction (STEMI) receiving center (SRC) network.

Prehospital Systems

The prehospital evaluation should consist of a focused history and physical examination, including a complete assessment of vital signs and a prehospital 12-lead electrocardiogram (PHECG). Earlier STEMI diagnosis based on the PHECG facilitates in-hospital STEMI treatment. Hospitals with the shortest door-to-balloon (D2B) times are those that have incorporated prehospital STEMI diagnosis with pre-activation of the cardiac catheterization laboratory (CCL). This strategy requires a multidisciplinary team approach in which either the emergency physician or specially trained EMS providers activate the CCL without cardiology consultation.

However, the rapid transport of STEMI patients to the nearest PPCI-capable facility may be limited by several factors. First, only a minority (≤5%) of EMS transported patients with chest pain actually have STEMI. Second, an inadequate number (∼50%) of EMS systems have PHECG capabilities. Third, in some regions a mandate still exists for transport of patients with suspected STEMI to the nearest facility, even if that facility does not provide PPCI. Fourth, evolution toward a more integrated process of prehospital care is complicated by the fact that there are 329 different EMS regions in the United States, with more than 993 hospital-based EMS systems. Remarkably, hospital-based EMS systems represent only 6.5% of all EMS providers, with the remainder comprised of private, third party systems (48.6%) and fire station–based systems (44.9%).

Integrated Emergency Medical Systems

Although the transport time to a specialized PPCI center may appear long, the benefits outweigh the drawbacks when an integrated EMS system incorporates pre-notification, termed “parallel processing.” Some have proposed doubling the allotted transport time for suspected STEMI patients, to allow transportation of these patients directly to a “center of excellence,” where the target D2B time is ≤60 minutes. Process efficiency can be achieved only through an integrated system for STEMI care that incorporates the PHECG for earlier diagnosis, expedited triage, and readily available, rehearsed transport systems. A more uniform evolution toward integrated STEMI care has been impeded by a lack of funding, diverging incentives, a lack of coordinated objectives, and at times, competing strategies. For example, in many regions, particularly those without state-regulated certificate of need requirements, there has been a proliferation of new catheterization laboratories for the provision of PPCI without regard for PPCI volume or surgical backup. Conversely, other regions have developed integrated EMS systems that focus on prehospital diagnosis, triage, and transfer to an established center of excellence proficient in both primary and elective PCI. Although expansion of PPCI-capable centers can improve access to care, more efficient use of existing PPCI centers through prehospital–EMS integration has been proven to be a more cost-effective strategy. Only recently have sophisticated modeling techniques been used to compare the relative efficacy and/or cost of these competing strategies for the care of STEMI patients. Importantly, a strategy focused on EMS integration, prehospital diagnosis, triage, and transportation with more effective use of existing PPCI facilities was found to be more effective and less costly than a strategy of creating new PPCI facilities ( Figure 5-e5 ).

The coordination of strategies, as well as the integration of essential prehospital and in-hospital resources for ACS care on the state level has been the focus of the AHA Mission: Lifeline initiative, which was created as a response to missed opportunities for prompt, appropriate STEMI treatment. The Mission: Lifeline goal is to improve outcomes for STEMI patients by building integrated care networks through community outreach, training, and education of civilians and EMS personnel. The AHA Mission: Lifeline also provides a blueprint for hospitals and administrators to implement systems of care. At present, approximately 65% of U.S. citizens have access to a Mission: Lifeline system of care, the number of which has increased greatly over the past decade ( Figure 5-5 ).

FIGURE 5-5, Mission: Lifeline coverage map.

Although the AHA’s Mission: Lifeline has been instrumental in the proliferation of STEMI systems of care throughout the country, the ACC’s Door-to-Balloon Alliance sought to improve D2B times in PPCI hospitals. The D2B Alliance was launched in 2006, in partnership with the Institute for Healthcare Improvement. This Alliance provided hospitals with evidence-based strategies and supporting tools needed to reduce D2B times through a focus on process improvement, parallel processing, and interdisciplinary collaboration. The keys to reducing D2B times are (1) the emergency department (ED) physician (or EMS PHECG) activates the CCL, (2) one call activates the entire team, (3) the CCL team is ready within 30 minutes of receiving the activation call, (4) prompt data feedback, and (5) a team-based approach with commitment from all levels. When launched, the initial goal was to achieve D2B times of ≤90 minutes for 75% of STEMI patients presenting to a PPCI facility. In the decade since its inception, the D2B Alliance has facilitated dramatic improvements in D2B times across the country (see Figure 5-1 ). Through the efforts of these organizations, as well as the individual efforts of countless nurses, doctors, administrators, and EMS providers, the STEMI receiving network system of care model has blossomed both domestically and abroad.

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