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Prazosin
See also Alpha-adrenoceptor antagonists
General information
Prazosin is an alpha 1 -adrenoceptor antagonist. Its main uses are in the treatment of hypertension, congestive cardiac failure, Raynaud’s syndrome, and the symptoms of benign prostatic hyperplasia, but it has also been used in the management of post-traumatic stress disorder [ ].
Organs and systems
Cardiovascular
Postural hypotension and reflex tachycardia, particularly on standing, are features of the first-dose response to prazosin, but adaptive receptor responses lead to re-setting of the reflex mechanisms within the first few days of treatment, and there are therefore generally no significant changes in heart rate during long-term treatment. An orthostatic component to the hypotensive response persists during long-term treatment, and this may be significant and symptomatic if high dosages are used. It is less frequent with modified-release prazosin.
Acute, intermittent, sharp, left-sided chest pain has been attributed to prazosin 1 mg/day after treatment for 3 days in a 25-year-old man with post-traumatic stress disorder; it resolved after withdrawal [ ].
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