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Polycystic Ovarian Syndrome
D efinition — An apparent congenital disorder characterized by ovulatory dysfunction and biochemical evidence of androgen excess, often with polycystic ovaries detected by ultrasound.
Clinical Features
Epidemiology
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First described by Stein and Leventhal.
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Can be seen in generations of families, suggesting an autosomal mode of inheritance in such cases.
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However, no single gene has been consistently linked to this disorder.
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Underlying defect is hyperandrogenism associated with ovulatory dysfunction, follicular arrest, and oligomenorrhea.
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Most common endocrinopathy in reproductive-age women, affecting from 2% to 20% of this group and up to 3.5% of women worldwide.
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