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p53 Signatures
D efinition — A limited clonal expansion of secretory cells associated with mutations in p53 exhibiting minimal or atypia. Seen as perhaps the very first step in serous carcinogenesis in the tube; often termed a “latent precursor” to pelvic serous carcinoma.
Clinical Features
Epidemiology
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p53 signatures exhibit features consistent with very early or latent serous cancer precursors. They are common (up to 70%) in thoroughly sectioned fallopian tubes of older women, predominate in the fimbria, exhibit evidence of DNA damage response, and are more frequently found in association with cancer. However, they are benign and their high frequency indicates that this entity, like many precursors, confers no risk to the patient.
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