Obsessive-compulsive Disorder and Obsessive-compulsive and Related Disorders


Key Points

  • Obsessive-compulsive disorder (OCD) and obsessive-compulsive-related disorders (OCRDs) now comprise an independent disease category within the DSM-5, as OCD is no longer classified as an anxiety disorder. OCRDs include hoarding disorder (HD), and three body-focused disorders: body dysmorphic disorder (BDD), trichotillomania (hair-pulling disorder) (TTM) and skin-picking (excoriation) disorder (SPD).

Incidence

  • OCD and OCRDs are common yet under-recognized, with individual prevalence rates in the range of approximately 1%–2%, except for HD with a reported prevalence of 2%–6%. These rates appear consistent across countries and socioeconomic strata. Moreover, these disorders are highly co-morbid with each other.

Epidemiology

  • OCD has peaks of onset in pre-adolescence and early adulthood, whereas the OCRDs typically present in adolescence around puberty. There is no clear gender predominance for either OCD or BDD, although OCD begins earlier in boys than girls. Females are at higher risk for HD, TTM, and SPD, especially in clinical settings.

Pathophysiology

  • Research indicates that genetic and environmental factors are fairly equally involved in the etiology of OCD. The orbitofrontal cortex, anterior cingulate cortex, basal ganglia, and thalamic brain structures have been implicated, with dysfunction in corticostriatal pathways including a ventromedial “emotion” circuit and a dorsolateral “cognitive” circuit. Autoimmune processes may play a role in some acute, early-onset, cases. OCRDs have some overlapping and some distinct features with respect to pathophysiology, although studies are preliminary.

Clinical Findings

  • Mental status and clinical observation may reveal signs of OCD and OCRDs that differ across individuals and may include red, chapped hands from washing in OCD, cognitive difficulties in HD, dressing in overly concealing clothing in BDD, localized or diffuse areas of baldness in TTM, and extensive scarring and excoriations in SPD.

Differential Diagnoses

  • OCD and the OCRDs are characterized by repetitive thoughts and behaviors, and have several overlapping features. Other disorders to consider in the differential diagnosis include eating disorders, autism spectrum disorder, generalized anxiety disorder, impulse control disorders and psychotic disorders.

Treatment Options

  • The two main treatment approaches for OCD include cognitive-behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs), used alone or in combination. OCD exhibits a linear dose-response curve such that higher doses tend to have greater efficacy. CBT is recommended for all OCRDs, although SRIs may be less effective for the management of HD, BDD, TTM, and SPD. There is early evidence for SRI augmentation with atypical antipsychotics and glutamatergic agents for some of these disorders.

Complications

  • Delay to diagnosis and treatment is very common, and associated with worse outcomes.

  • Access to trained CBT providers for these disorders is frequently challenging. Common prescribing errors include SRI trial attempts with an insufficient duration (<12 weeks) or dosage.

Prognosis

  • OCD and OCRDs tend to have chronic courses that wax and wane, although approximately half of OCD cases become subthreshold or remit. Suicide risk is elevated in BDD and HD severity tends to worsen with age.

Overview

Obsessive-compulsive disorder (OCD) is a common disorder that affects individuals throughout the life span. This disorder has been listed as one of the 10 most disabling illnesses by the World Health Organization. Obsessive-compulsive-related disorders (OCRDs) include hoarding disorder (HD) and body-focused disorders, including body dysmorphic disorder (BDD), trichotillomania (hair-pulling disorder [TTM]) and excoriation (skin-picking) disorder (SPD).

Approximately 1% to 3% of the world's population will be affected by OCD at some point in their lives, and a greater number will suffer from OCRDs. Due to both under-recognition by clinicians and the shame-induced tendency for individuals to hide OCD and OCRD symptoms, the delay in diagnosis and treatment is frequently staggeringly long. The reported mean delay from symptom onset to diagnosis and appropriate treatment is 17 years. Although these disorders tend to have a waxing and waning course, they frequently increase in severity when left untreated, adding to the burden of illness for affected individuals and their family members. The present chapter gives a general description of OCD and OCRDs, followed by characterization of related epidemiology, risk factors, pathophysiology, and clinical features. Practical strategies for clinical evaluation and treatment of these illnesses are then discussed.

Clinical Features and Diagnosis

OCD is characterized by recurrent unwanted thoughts, urges, images, and repetitive behaviors or mental acts that are distressing, time-consuming, and affect functioning. The condition is often kept secret because of the shame associated with its particular symptoms. Symptoms experienced by OCD-affected individuals are diverse, with three main groups or “dimensions” that tend to co-occur, including contamination obsessions with cleaning compulsions ( Figure 33-1 ); symmetry obsessions, with ordering and repeating compulsions; and intrusive thoughts related to religious, sexual, aggressive, and somatic themes with checking compulsions. Other common OCD compulsions include reassurance-seeking, counting, praying, mental rituals, and “just right” rituals. OCD-affected individuals frequently experience multiple symptoms at any given time, many of which are driven by the perceived need to achieve certainty, and symptom types tend to change over the course of the illness.

Figure 33-1, Obsessive-compulsive disorder patient demonstrating a typical compulsive behavior of handwashing. Some patients may wash their hands hundreds of times daily, leading to inflamed, erythematous, and cracking skin.

OCRDs are predominantly characterized by the presence of repetitive behaviors, some of which are related to body appearance concerns (BDD), and some of which are associated with repeated attempts to decrease or stop the body-focused behavior (TTM and SPD). What constitutes an OCRD has been a controversial subject. The OCRDs as discussed in this chapter comprise those outlined in the Diagnostic and Statistical Manual of Mental Disorders , Fifth Edition (DSM-5) and include hoarding disorder (HD) and the body-focused disorders—body dysmorphic disorder (BDD), trichotillomania (hair-pulling disorder [TTM]) ( Figure 33-2 ) and excoriation (skin-picking) disorder (SPD). Additional OCRDs listed in the DSM-5 (those secondary to a medication, a substance, or a medical condition) will not be discussed here.

Figure 33-2, Left-side view of a trichotillomania patient's scalp demonstrating areas of alopecia (balding) and hair thinning.

HD is a disorder in which individuals have a persistent resistance to, and distress associated with, discarding possessions, regardless of their value. These individuals also experience a strong urge to save items, often resulting in extensive accumulation of items, and clutter in their living areas. Figure 33-3 illustrates the living quarters of a patient with HD.

Figure 33-3, Cluttered and overcrowded home of a hoarding disorder patient.

BDD is a disorder in which individuals suffer from a preoccupation with a slight or imagined defect in appearance that causes significant distress or impairment that is not strictly a manifestation of another disorder.

TTM and SPD present with an inability to resist the urge to recurrently pull hair or to pick the skin, respectively, despite recurrent attempts to stop. The differential diagnosis for SPD includes delusional parasitosis. All of these OCRDs are significantly distressing, impairing, and adversely affect quality of life. Although many individuals with TTM and SPD report urges to pull or pick prior to, and a sense of relief during, the behavior, these symptoms are not universal.

The publication of the DSM-5 reflects a large shift in the conceptualization of OCD and related disorders, with the emergence of a dedicated chapter and category for these illnesses. Newly defined DSM-5 diagnoses include HD, SPD, substance-/medication-induced OC and related disorder, OC and related disorder due to another medical condition and unspecified OCRDs (such as olfactory reference syndrome and body-focused repetitive behavior disorder). Classification of OCD has been removed from the anxiety disorders; BDD has been moved from the somatoform disorders; and TTM has been moved from the impulse-control disorders. In addition, for OCD, HD and BDD, specifiers related to insight have been expanded to include three options of good or fair insight, poor insight, and absent insight/delusional beliefs. Moreover, new specifiers include a tic-related specifier for OCD, a “with excessive acquisition” specifier for HD and a muscle dysmorphia specifier for BDD.

A summary of diagnostic criteria changes between DSM-IV and DSM-5 for OCD, BDD, and TTM is provided in Tables 33-1 to 33-3 , respectively. DSM-5 diagnostic criteria for OCD appears in Box 33-1 , BDD appears in Box 33-2 , and TTM appears in Box 33-3 . Diagnostic criteria for the new DSM-5 disorders HD and SPD are provided in Box 33-4 and 33-5 .

TABLE 33-1
Obsessive-Compulsive Disorder Criteria for DSM-IV and DSM-5
DSM-IV DSM-5 (300.3(F42)) Summary of Changes
Disease Category
anxiety disorders obsessive - compulsive and related disorders new chapter created
D iagnostic C riteria for O bsessive - compulsive D isorder [300.3]
Either Obsessions or Compulsions
Obsessions are defined by the following:
Recurrent and persistent thoughts, impulses , or images that are experienced, at some time during the disturbance, as intrusive and inappropriate and that cause marked anxiety or distress Recurrent and persistent thoughts, urges , or images that are experienced, at some time during the disturbance, as intrusive and unwanted , and that in most individuals cause marked anxiety or distress
  • “Impulses” replaced by “urges”

  • “Inappropriate” changed to “unwanted”

  • Always cause marked anxiety or distress changed to "in most individuals"

The effort by the affected person to ignore or suppress such thoughts, impulses , or images, or to neutralize them with some other thought or action The individual attempts to ignore or suppress such thoughts, urges, or images, or to neutralize them with some other thought or action (i.e., by performing a compulsion )
  • “Impulses” replaced by “urges”

  • Neutralizing may include performing a compulsion

Thoughts, impulses, or images that are not simply excessive worries about real-life problems
  • Criteria removed that would exclude individuals with generalized anxiety disorder moved to exclusion criteria section

Recognition by the affected person that the obsessional thoughts, impulses, or images are a product of his or her own mind rather than imposed from without
  • Criteria removed that would exclude individuals with no insight

Compulsions are defined by the following:
Repetitive activities (e.g., handwashing, ordering, checking) or mental acts (e.g., praying, counting, repeating words silently) that the person feels driven to perform in response to an obsession or according to rigid rules that must be applied rigidly Repetitive behaviors (e.g., handwashing, ordering, checking) or mental acts (e.g., praying, counting, repeating words silently) that the individual feels driven to perform in response to an obsession or according to rules that must be applied rigidly
  • Activities changed to behaviors

Behavior or mental acts aimed at preventing or reducing distress or preventing some dreaded event or situation but either clearly excessive or not connected in a realistic way with what they are designed to neutralize or prevent The behaviors or mental acts are aimed at preventing or reducing anxiety or distress, or preventing some dreaded event or situation; however, these behaviors or mental acts are not connected in a realistic way with what they are designed to neutralize or prevent, or are clearly excessive. NOTE: Young children may not be able to articulate the aims of these behaviors or mental acts
  • Notation that children can not always explain why they have compulsions

Recognition , by the affected person (unless he or she is a child), at some point during the course of the disorder, that the obsessions or compulsions are excessive or unreasonable
  • No longer need to recognize as excessive; symptoms

S pecifiers
Specified as obsessive-compulsive disorder (OCD) with poor insight if, for most of the time during the current episode, the person does not recognize that the obsessions and compulsions are excessive or unreasonable With good or fair insight: The individual recognizes that obsessive-compulsive disorder beliefs are definitely or probably not true or that they may or may not be true
With poor insight: The individual thinks obsessive-compulsive disorder beliefs are probably true
With absent insight/delusional beliefs: The individual is completely convinced that obsessive-compulsive disorder beliefs are true
  • Specifiers refined to distinguish between good to fair insight, poor insight and “absent insight/delusional” OCD beliefs

  • Absent insight now an “option” while retaining OCD diagnosis

Tic-related: The individual has a current or past history of a tic disorder.
  • New tic specifier added

F unctional I mpact /E xclusion C riteria
Obsessions or compulsions that cause marked distress, are time-consuming (take more than 1 hour per day), or interfere substantially with the person's normal routine, occupational or academic functioning, or usual social activities or relationships The obsessions or compulsions are time-consuming (e.g., take more than 1 hour per day) or cause clinically significant distress or impairment in social, occupational, or other important areas of functioning
Content of the obsessions or compulsions not restricted to any other Axis I disorder, such as an obsession with food in the context of an eating disorder that is present The disturbance is not better explained by the symptoms of another mental disorder (e.g., excessive worries, as in generalized anxiety disorder, preoccupation with appearance, as in body dysmorphic disorder; difficulty discarding or parting with possessions, as in hoarding disorder; hair pulling, as in trichotillomania [hair-pulling disorder]; skin picking, as in excoriation [skin-picking] disorder; stereotypies, as in stereotypic movement disorder; ritualized eating behaviour, as in eating disorders; preoccupation with substances or gambling, as in substance-related and addictive disorders; preoccupation with having an illness, as in illness anxiety disorder; sexual urges or fantasies, as in paraphilic disorders; impulses, as in disruptive, impulse-control, and conduct disorders; guilty ruminations, as in major depressive disorder; thought insertion or delusional preoccupations, as in schizophrenia spectrum and other psychotic disorders; or repetitive patterns of behaviour, as in autism spectrum disorder)
  • More examples provided

Disturbance not due to the direct physiological effects of a substance or a general medical condition The obsessive-compulsive symptoms are not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication) or another medical condition
  • Examples of substances added (e.g., a drug of abuse, a medication)

TABLE 33-2
Body Dysmorphic Disorder Criteria for DSM-IV and DSM-5
DSM-IV DSM-5 (300.7(F45.22)) Summary of Changes
Disease Category
somatoform disorders obsessive - compulsive and related disorders
B ody D ysmorphic D isorder [300.7] D iagnostic C riteria
Preoccupation with an imagined defect in appearance. If a slight physical anomaly is present, the person's concern is markedly excessive Preoccupation with one or more perceived defects or flaws in physical appearance that are not observable or appear slight to others
  • Potential for more than one physical focus of attention clarified

At some point during the course of the disorder, the individual has performed repetitive behaviors (e.g., comparing his or her appearance with that of others) in response to the appearance concerns
  • Addition of repetitive behavior criterion, reflecting inclusion as an obsessive-compulsive-related disorder

F unctional I mpact /E xclusion C riteria
The preoccupation causes clinically significant distress or impairment in social, occupational, or other important areas of functioning The preoccupation causes clinically significant distress or impairment in social, occupational, or other important areas of functioning
  • None

The preoccupation is not better accounted for by another mental disorder (e.g., dissatisfaction with body shape and size in anorexia nervosa) The appearance preoccupation is not better explained by concerns with body fat or weight in an individual whose symptoms meet diagnostic criteria for an eating disorder
  • Clarification of eating disorder exclusion

S pecifiers
With muscle dysmorphia: The individual is preoccupied with the idea that his or her body build is too small or insufficiently muscular. This specifier is used even if the individual is preoccupied with other body areas, which is often the case
  • New specifier that predominantly occurs in males

With good or fair insight: The individual recognizes that the body dysmorphic disorder beliefs are definitely or probably not true or that they may or may not be true
With poor insight: The individual thinks that the body dysmorphic disorder beliefs are probably true
With absent insight/delusional beliefs:
The individual is completely convinced that the body dysmorphic disorder beliefs are true
  • Specifiers refined to distinguish between good to fair insight, poor insight and “absent insight/delusional” body dysmorphic disorder beliefs

  • Absent insight now an “option” without requiring a concurrent coding of a delusional disorder somatic type diagnosis

TABLE 33-3
Trichotillomania (Hair-Pulling Disorder) Criteria for DSM-IV and DSM- 5
DSM-IV DSM-5 (312.39(F63.2)) Summary of Changes
Disease Category
impulse - control disorders not elsewhere classified obsessive - compulsive and related disorder hair - pulling disorder has been added parenthetically
T richotillomania (H air -P ulling D isorder ) [312.39] D iagnostic C riteria
Recurrent pulling out of one's hair resulting in noticeable hair loss Recurrent pulling out of one's hair, resulting in hair loss
  • “Noticeable” removed as descriptor of hair loss

Repeated attempts to decrease or stop hair pulling
  • New criterion

An increasing sense of tension immediately before pulling out the hair or when attempting to resist the behavior
  • Criterion removed

Pleasure, gratification, or relief when pulling out the hair
  • Criterion removed

F unctional I mpact /E xclusion C riteria
The disturbance is not better accounted for by another mental disorder and is not due to a general medical condition (e.g., a dermatological condition) The hair pulling or hair loss is not attributable to another medical condition (e.g., a dermatological condition).
The hair pulling is not better explained by the symptoms of another mental disorder (e.g., attempts to improve a perceived defect or flaw in appearance in body dysmorphic disorder)
  • Example of mental disorder provided

The disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning The hair pulling causes clinically significant distress or impairment in social, occupational, or other important areas of functioning
  • None

Box 33-1
Reprinted with permission from the Diagnostic and statistical manual of mental disorders , ed 5, (Copyright 2013). American Psychiatric Association.
DSM-5 Diagnostic Criteria
Obsessive-compulsive Disorder (300.3 (F42) )

  • A.

    Presence of obsessions, compulsions, or both:

    Obsessions are defined by (1) and (2):

    • 1.

      Recurrent and persistent thoughts, urges, or images that are experienced, at some time during the disturbance, as intrusive and unwanted, and that in most individuals cause marked anxiety or distress.

    • 2.

      The individual attempts to ignore or suppress such thoughts, urges, or images, or to neutralize them with some other thought or actions (i.e., by performing a compulsion).

    Compulsions are defined by (1) and (2):

    • 1.

      Repetitive behaviors (e.g., hand washing, ordering, checking) or mental acts (e.g., praying, counting, repeating words silently) that the individual feels driven to perform in response to an obsession or according to rules that must be applied rigidly.

    • 2.

      The behaviors or mental acts are aimed at preventing or reducing anxiety or distress, or at preventing some dreaded event or situation; however, these behaviors or mental acts are not connected in a realistic way with what they are designed to neutralize or prevent, or are clearly excessive.

    Note: Young children may not be able to articulate the aims of these behaviors or mental acts.

  • B.

    The obsessions or compulsions are time-consuming (e.g., take more than 1 hour per day) or cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.

  • C.

    The obsessive-compulsive symptoms are not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication) or another medical condition.

  • D.

    The disturbance is not better explained by the symptoms of another mental disorder (e.g., excessive worries, as in generalized anxiety disorder; preoccupation with appearance, as in body dysmorphic disorder; difficulty discarding or parting with possessions, as in hoarding disorder; hair pulling, as in trichotillomania [hair-pulling disorder]; skin picking as in excoriation [skin-picking] disorder; stereotypies, as in stereotypic movement disorder; ritualized eating behavior, as in eating disorders; preoccupation with substances or gambling, as in substance-related and addictive disorders; preoccupation with having an illness, as in illness anxiety disorder; sexual urges or fantasies, as in paraphilic disorders; impulses, as in disruptive, impulse-control, and conduct disorders; guilty ruminations, as in major depressive disorder; thought insertion or delusional preoccupations, as in schizophrenia spectrum and other psychotic disorders; or repetitive patterns of behavior, as in autism spectrum disorder).

Specify if:

  • With good or fair insight: The individual recognizes that obsessive-compulsive disorder beliefs are definitely or probably not true or that they may or may not be true.

  • With poor insight: The individual thinks obsessive-compulsive disorder beliefs are probably ture.

  • With absent insight/delusional beliefs: The individual is completely convinced that obsessive-compulsive disorder beliefs are true.

Specify if:

  • Tic-related: The individual has a current or past history of a tic disorder.

Box 33-2
Reprinted with permission from the Diagnostic and statistical manual of mental disorders , ed 5, (Copyright 2013). American Psychiatric Association.
DSM-5 Diagnostic Criteria
Body Dysmorphic Disorder (300.7 (F45.22) )

  • A.

    Preoccupation with one or more perceived defects or flaws in physical appearance that are not observable or appear slight to others.

  • B.

    At some point during the course of the disorder, the individual has performed repetitive behaviors (e.g., mirror checking, excessive grooming, skin picking, reassurance seeking) or mental acts (e.g., comparing his or her appearance with that of others) in response to the appearance concerns.

  • C.

    The preoccupation causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

  • D.

    The appearance preoccupation is not better explained by concerns with body fat or weight in an individual whose symptoms meet diagnostic criteria for an eating disorder.

Specify if:

  • With muscle dysmorphia: The individual is preoccupied with the idea that his or her body build is too small or insufficiently muscular. This specifier is used even if the individual is preoccupied with other body areas, which is often the case.

Specify if:

Indicate degree of insight regarding body dysmorphic disorder beliefs (e.g. “I look ugly” or “I look deformed”).

  • With good or fair insight: The individual recognizes that the body dysmorphic disorder beliefs are definitely or probably not true or that they may or may not be true.

  • With poor insight: The individual thinks that the body dysmorphic disorder beliefs are probably true.

  • With absent insight/delusional beliefs: The individual is completely convinced that the body dysmorphic disorder beliefs are true.

Box 33-3
Reprinted with permission from the Diagnostic and statistical manual of mental disorders , ed 5, (Copyright 2013). American Psychiatric Association.
DSM-5 Diagnostic Criteria
Trichotillomania (Hair-Pulling Disorder) (312.39 (F63.2) )

  • A.

    Recurrent pulling out of one's hair resulting in hair loss.

  • B.

    Repeated attempts to decrease or stop hair pulling.

  • C.

    The hair pulling causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

  • D.

    The hair pulling or hair loss is not attributable to another medical condition (e.g., a dermatological condition).

  • E.

    The hair pulling is not better explained by the symptoms of another mental disorder (e.g., attempts to improve a perceived defect or flaw in appearance in body dysmorphic disorder).

Box 33-4
Reprinted with permission from the Diagnostic and statistical manual of mental disorders , ed 5, (Copyright 2013). American Psychiatric Association.
DSM-5 Diagnostic Criteria
Hoarding Disorder Diagnostic Criteria (300.3 (F42) )

  • A.

    Persistent difficulty discarding or parting with possessions, regardless of their actual value.

  • B.

    This difficulty is due to a perceived need to save items and to the distress associated with discarding them.

  • C.

    The difficulty discarding possessions results in the accumulation of possessions that congest and clutter active living areas and substantially compromises their intended use. If living areas are uncluttered, it is only because of the interventions of third parties (e.g., family members, cleaners, authorities).

  • D.

    The hoarding causes clinically significant distress or impairment in social, occupational, or other important areas of functioning (including maintaining a safe environment for self and others).

  • E.

    The hoarding is not attributable to another medical condition (e.g., brain injury, cerebrovascular disease, Prader-Willi syndrome).

  • F.

    The hoarding is not better explained by the symptoms of another mental disorder (e.g., obsessions in obsessive-compulsive disorder, decreased energy in major depressive disorder, delusions in schizophrenia or another psychotic disorder, cognitive deficits in major neurocognitive disorder, restricted interests in autism spectrum disorder).

Specify if:

  • With excessive acquisition : If difficulty discarding possessions is accompanied by excessive acquisition of items that are not needed or for which there is no available space.

Specify if:

  • With good or fair insight : The individual recognizes that hoarding-related beliefs and behaviors (pertaining to difficulty discarding items, clutter, or excessive acquisition) are problematic.

  • With poor insight : The individual recognizes that hoarding-related beliefs and behaviors (pertaining to difficulty discarding items, clutter, or excessive acquisition) are not problematic despite evidence to the contrary.

  • With absent insight/delusional beliefs : The individual is completely convinced that hoarding-related beliefs and behaviors (pertaining to difficulty discarding items, clutter or excessive acquisition) are not problematic despite evidence to the contrary.

Box 33-5
DSM-5 Diagnostic Criteria
Excoriation (Skin-picking) (698.4 (L98.1) )

  • A.

    Recurrent skin picking resulting in skin lesions:

  • B.

    Repeated attempts to decrease or stop skin picking.

  • C.

    The skin picking causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

  • D.

    The skin picking is not attributable to the physiological effects of a substance (e.g., cocaine) or another medical condition (e.g., scabies).

  • E.

    The skin picking is not better explained by symptoms of another mental disorder (e.g., delusions or tactile hallucinations in a psychic disorder, attempts to improve a perceived defect or flaw in appearance in body dysmorphic disorder, sterotypes in stereotypic movement disorder, or intention to harm oneself in non-suicidal self-injury).

Epidemiology and Risk Factors

Prevalence

Symptoms of OCD are common. Approximately 50% of the general population engage in some ritualized behaviors, and up to 80% experience intrusive, unpleasant, or unwanted thoughts. However, these behaviors do not cause excessive distress, occupy a significant amount of time, or impair function for most individuals, and as such they do not represent OCD. Regarding a clinical diagnosis of OCD in adults, the 1-month prevalence rate is 0.6%, and the reported 12-month prevalence ranges from 0.6% to 1.0% for DSM-IV–defined OCD and from 0.8% to 2.3% for DSM-III-R–defined OCD.

Measured life-time prevalence rates for OCD appear to have depended on the version of the DSM used to determine diagnoses. The estimated life-time prevalence is 1.6% using the DSM-IV. Using the DSM-III, the life-time rate was 2.5% in the US Epidemiologic Catchment Area Survey, and the prevalence ranged between 0.7% (in Taiwan) and 2.5% (in Puerto Rico and in seven other countries surveyed). These differences may be due to the fact that the DSM-IV better defined obsessions and compulsions and required significant clinical distress or impairment to confirm a diagnosis.

The prevalence rates of the OCRDs vary. Many of these disorders co-occur with each other and with OCD. HD prevalence rates have been reported between 2% and 6%, based upon studies in US and Europe. Prevalence of BDD is difficult to accurately estimate given the secrecy of the disorder, although estimates are approximately 2.3% in the general population, and range from 6% to 15% in cosmetic surgery settings. The exact life-time prevalence of TTM is unknown, but rates of DSM-IV-defined TTM range from 1% to 2%. The prevalence is even higher for subclinical hair-pulling, as preceding tension and subsequent gratification are often absent. Notably, DSM-5 has removed these criteria. SPD has an estimated prevalence of 1.4%. In patients with OCD, the prevalence of co-morbid broadly-defined OCRDs exceeds that for the general population, with reported rates of over 55%.

Age of Onset

There appears to be a bi-modal age of onset for OCD. Approximately one-third to one-half of adults with OCD develop the disorder in childhood. The National Comorbidity Survey Replication reported a median onset at the age of 19 years, with 21% of cases emerging by age 10. Pediatric OCD has a median onset in pre-adolescence. For those who first develop OCD in adulthood, the mean onset age of OCD occurs between 22 and 35 years of age. A few studies report another incidence peak in middle to late adulthood, but it is commonly believed that OCD onset after 50 years old is relatively unusual.

The age of onset for individuals with OCD appears to be an important clinical variable. Childhood-onset OCD may have a unique etiology and outcome, and it may represent a developmental subtype of the disorder. Childhood-onset OCD is also associated with greater severity and with higher rates of compulsions without reported obsessions. Earlier age of onset within a pediatric sample was associated with higher persistence rates in a meta-analysis of long-term outcomes for childhood-onset OCD. Co-morbid rates of tic disorders, attention-deficit/hyperactivity disorder (ADHD), and anxiety disorders are also higher compared to adult OCD.

HD symptoms tend to begin early in life, between 11 and 15 years of age, increasing in severity with each decade. HD is reportedly three times more common in older adults (between 55 and 94 years) compared to younger adults (between 34 and 44 years old).

BDD tends to present during adolescence. Many individuals with BDD have had life-long sensitivities regarding their appearance. The age of onset for adults with TTM is approximately 13 years. TTM and SPD often begin around the age of puberty.

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