Minor p16-Positive Metaplastic Atypias


D efinition —Immature metaplastic or reserve cell proliferations with mild atypia and strong p16 immunostaining.

Clinical Features

Epidemiology

  • Reproductive-age women.

  • Inconsistent human papillomavirus (HPV) association.

  • Typically present with atypical squamous cells of undetermined significance (ASCUS) cervical smear.

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