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Metastatic Brain Tumors
Definition
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Hematogenous spread of a primary tumor originating outside the CNS to the brain or its coverings
Clinical Features
Epidemiology
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Most common brain tumors in adults
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Incidence of about 10 to 30 per 100,000 per year
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CNS metastases found in about 25% of patients who die of cancer
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Most common primary sites: lung (50%), breast (15%), skin (melanoma) (11%), unknown primary site (11%), kidney, GI tract in adults
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Children may develop metastatic disease from leukemia, lymphoma, osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma
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About 85% occur in the cerebral hemispheres: most within frontoparietal regions in middle cerebral artery distribution
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15% cerebellum and brain stem
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Often found within watershed zones
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