Melatonin ( N -Acetyl-5-Methoxytryptamine, Bevitamel, Vitamist, Melatonex)

Regulates sleep-wake cycles.

Prescribed for jet lag, shift work, depression.

Use as antineoplastic, antidelirium, and anticonvulsant is under investigation.

Questionable benefit in treating breast cancer and migraines.

Categorized as a nutraceutical (unregulated).

Not controlled by FDA; therefore quality and potency may vary.

May interact with other CNS-acting medications such as hypnotics, sedatives, or psychotropics.

Not recommended in children or pregnant/breastfeeding women owing to insufficient data

May cause excessive somnolence.

Use of animal-source melatonin products is not recommended because of risk of viral contamination or infection.