Maternal Mortality: A Global Perspective


Key Abbreviations

Acquired immune deficiency syndrome AIDS
Emergency obstetric care EmOC
Female genital mutilation/cutting FGM/FGC
International Federation of Obstetricians and Gynecologists FIGO
Global Library of Women's Medicine GLOWM
Gross national income GNI
Human immunodeficiency virus HIV
International Conference on Population and Development ICPD
Intrauterine device IUD
Long-acting reversible contraception LARC
Low-income country LIC
Millennium Development Goals MDGs
Middle-income country MIC
Maternal mortality ratio MMR
Postpartum hemorrhage PPH
Traditional birth attendant TBA
Tuberculosis TB
World Health Organization WHO
United Nations UN

This chapter can only touch the surface of the complex issues relating to the continuing, yet generally avoidable, tragedy of maternal deaths worldwide—a scandal of epic proportions in a 21st century world. For those readers for whom it provides the fire and impetus for more in-depth study, many key documents and papers are contained within its references. We offer a brief description of the main clinical, health system, and wider social causes of maternal death and obstetric complications, particularly in resource-poor countries, and the key actions to prevent or treat these. This includes a summary of the crucial steps that need to be taken at an individual, professional, facility, and health system level, both nationally and internationally. We describe the clinical challenges of preventing, identifying, and managing the main obstetric complications of pregnancy, applicable to low- and middle-income countries but also relevant in developed settings.

Maternal Health and the Burden of Death and Disability

“Many Births Mean Many Burials” —Kenyan Proverb

Every year worldwide, it is estimated that more than 300,000 mothers die from preventable causes during pregnancy, birth, and the postnatal period—approximately 830 women every day. Despite ongoing efforts by the global health community, the death rate has dropped by only 44% overall since 1975, far less than the 75% decline anticipated after the introduction of the United Nation (UN) Millennium Development Goals (MDGs) in 1990. Despite recent initiatives, which in some resource-poor countries have resulted in quite significant declines over the past few years, too little has happened too late. The irrefutable fact is that the main preventive or remediable interventions to reduce maternal deaths have been well known for many years, and nearly all of these tragedies could be avoided at little or no extra cost. Lives would be saved in those countries which carry a significant burden of maternal and newborn deaths if there was stronger political will to improve the lives of women by placing women's health and reproductive rights far higher up the agenda rather than at the tail end of services, as so often happens. As the father of the Safe Motherhood movement, Professor Mahmoud Fathalla famously said “women are not dying of diseases we cannot treat…they are dying because societies have yet to decide that their lives are worth saving.”

Maternal deaths and disabilities are eminently avoidable if women have a choice about becoming pregnant and, once pregnant, if they have access to essential health services that provide evidence-based, technologically appropriate, and affordable interventions even in the poorest countries of the world. For example, a UN report estimated that if all women who wanted to space or avoid pregnancy were able to access and use an effective modern method of contraception, the global number of unintended pregnancies would drop by 70% and the number of unsafe, potentially fatal abortions would drop by 74%. In addition, if all pregnant women and their newborn babies received only the basic standards of maternity care recommended by the World Health Organization (WHO), the number of women dying would fall by two-thirds and those of their babies would decrease by more than three-quarters.

Deaths are merely the tip of the iceberg. Globally it is estimated that more than 300 million women are living with short- or long-term pregnancy-related complications, with approximately 20 million new cases occurring each year. In addition, these figures generally do not include the poorly recognized or accepted burden of mental health. In most countries, postnatal depression, suicide from puerperal psychosis, and other mental health issues are not even acknowledged as pregnancy-related problems, and the stories of legions of women dying or suffering from these debilitating conditions remain untold.

Since maternal and newborn health are a dyad, babies are also affected by their mother's health in pregnancy and birth. It is estimated that 2.7 million newborns die, and another 2.6 million babies are stillborn annually, and many more millions are left motherless and far less able to thrive. The risk of death for preexisting children younger than age 5 is doubled if their mother dies in childbirth and is even more challenging for girls. Every maternal death or long-term complication is not only a tragedy for the mother, her partner, and her surviving children but is also an economic loss to her family, community, and society.

In Chichewa, the national language of Malawi, the word pakati refers to pregnancy. Its literal translation means “ in the middle between life and death. ” In other African countries, it is common to hear women in labor using euphemisms such as “ I am going to the river to fetch water; I may not come back, ” or childbirth is described as “ slipping on a banana skin at the edge of a cliff with no safety net. ” These concerns are all too real for many women, and “ a place between life and death ” is an accurate description of the 9 months of anxiety and fear that accompany pregnancy and delivery.

The World Bank classifies every economy as low, middle, or high income; as an indicator it uses gross national income (GNI) per capita because it is considered to be the single best gauge of economic capacity and progress. For the 11 million mothers who give birth each year in high-income countries, access to quality antenatal, intrapartum, and postnatal care for both mothers and babies is readily available and health outcomes are generally good. Another 34 million women deliver in middle-income countries (MICs), where hospital facilities with variable quality of care or resources such as staff, blood, drugs, or high-dependency units tend to be available. However, for the 90 million mothers in low-income countries (LICs), the situation is usually very different, with little or no access to even basic healthcare, which places the both mother and baby at significantly higher risk, and, of these mothers, approximately 830 will die and 16,000 will suffer severe and long-lasting complications from pregnancy, birth, or postnatal complications every day. In addition, every day, nearly 8000 babies will die around the time of birth, and another 7000 will be stillborn. Overall, this burden of maternal and neonatal mortality, including stillbirths, accounts for approximately 15,800 deaths each day, or 10 lives lost every minute . Most of these will be from preventable or treatable causes of maternal ill health. The film “Why Did Mrs. X Die: Retold” is available online in several languages ( vimeo.com/50848172 ), and it provides a simple introduction.

Where Mothers Die

Ninety-nine percent of maternal and newborn deaths occur in LICs and MICs. Their burden is described by the WHO maternal mortality ratio (MMR), which is the number of direct and indirect maternal deaths per 100,000 live births during pregnancy or up to and including 42 days after the end of pregnancy. The UN estimated an overall global MMR of 216 deaths per 100,000 live births, with a higher figure, 239, for developing countries compared with an average of 12 for the most developed in 2015. The highest regional MMR is 536 for sub-Saharan Africa, followed by rates between 175 to 187 per 100,000 live births for Southern Asia, the Caribbean, and Oceania. However, these figures hide wide intercountry and intracountry variations. Overall, Sierra Leone is estimated to have the highest MMR (1360), followed by the Central African Republic (882), Chad (856), Nigeria (814), and South Sudan (780). All 19 African countries have MMRs higher than 500 per 100,000 live births. Due to the sheer weight of their population, Nigeria and India have the largest number of maternal deaths each year at 58,000 (19%) and 45,000 (15%), respectively. However, India has made significant progress in reducing poor maternal health outcomes over recent years with a concerted effort at national, state, and local levels. The Indian MMR fell from 600 in 1990 to 174 in 2015, a 69% reduction. The equivalent figures for Nigeria show an MMR of 1350 in 1990 falling to 814 in 2015; a 40% decline.

Adolescent Girls

Apart from taking away their childhood, pregnant adolescent girls and their babies are far more likely to die and are at greater risk of complications than their older sisters. Indeed, maternal death is currently the leading cause of mortality for young girls in developing countries. Compared with mothers age 20 to 24 years, girls between 10 and 19 years have higher risks of obstructed labor, eclampsia, puerperal sepsis, systemic infection, and preterm delivery, and their babies also fare worse.

Lifetime Risk of Maternal Death

Global

Women in developing countries tend to start their pregnancies at a younger age and have more children, not necessarily a position they wish to be in but one that is determined by numerous, intertwined factors such as societal pressures and norms, lack of education, little access to effective contraception, and a lack of human or reproductive human rights. For many, their fate in all things is decided by their husbands, elders (grandmothers are particularly powerful), or male family members. In developing countries, on average, a 15-year-old girl faces a 1 : 180 per-pregnancy risk of dying from a pregnancy-related complication during her lifetime, rising to an average lifetime risk of 1 : 36 for those living in sub-Saharan Africa and 1 : 54 for those in fragile states due to war or health service breakdown. By contrast, the average risk in the most developed countries is 1 : 4900. In the very worst countries to be born, such as Sierra Leone, Chad, Niger, and Nigeria, the lifetime risk is between 1 : 17 and 1 : 23 despite the fact that these figures have actually been halved over the past 10 years.

United States of America

The WHO estimated the overall MMR for the USA to be 14 per 100,000 live births in 2015, greater than Western Europe and Australasia. Enhanced surveillance of maternal deaths through the Centers for Disease Control and Prevention Pregnancy Mortality Surveillance System found a pregnancy-related mortality ratio of 17 per 100,000 births for the 2011–2013 epoch. Although these figures are estimates, there is no doubt that the USA is one of the few countries whose MMR has increased rather than decreased in recent years. In addition, the risk of death during and shortly after pregnancy is higher in the USA than in many other developed nations, and there is a persistent disparity in risk between African American women and their white counterparts. Moreover, indicators of severe pregnancy complications that place women at risk of critical illness and death are increasing. Although there is a critical need for better data to provide a more accurate accounting and a more nuanced explanation for causes and trends, there are indications that the majority of maternal deaths are preventable by addressing factors related to providers, patients, and systems of care. Recent patient safety research demonstrates that placing an emphasis on continuous quality improvement, implementing consistent protocols for diagnosis, management (i.e., patient safety bundles), and providing for consultation or referral of complicated cases are all opportunities to improve maternal outcomes.

In the United States, as in many Western countries, deaths from chronic conditions, such as cardiac disease, which are aggravated by pregnancy but not directly due to pregnancy-only–related conditions such as hemorrhage, eclampsia, or sepsis, the so-called indirect deaths, are the leading cause of mortality. A major challenge is to identify those women with underlying conditions who need specialist care at an early stage, without eliminating the category of lower risk cases. To address this complex problem, a multidisciplinary group of senior healthcare and birth facility leaders has been convened as the US National Partnership for Maternal Safety under the guidance of the Council on Patient Safety in Women's Health Care to review and amend current recommendations and plan a national approach to implement strategies to address these issues.

Mothers Who Survive: Severe Maternal Morbidity

Although global maternal deaths may have been neglected until relatively recently, women suffering from severe maternal morbidity (SMM) and its long-term sequelae have fared even worse and such conditions are far more common. It is estimated that 1.1 million of the 136 million births each year are complicated by an SMM, a “near-miss” event where the mother survived either by chance or due to good medical care. A further 9.5 million women suffer slightly less-immediate life-threatening complications which are still severe, and 20 million mothers suffer long-term complications each year. Recent estimates put the burden of SMM in sub-Saharan Africa to be as high as 198 cases per 1000 births, compared with 12 in the United Kingdom.

But whatever the death to SMM ratio, as with maternal deaths, the numbers of women suffering from severe obstetric complications are far too high and the underlying causes disturbingly similar. Hence reducing the risk factors for death will also help to decrease the number of significant obstetric complications and their long-term sequelae. Estimates of the overall numbers and case fatality rates for the five major global direct obstetric complications of pregnancy and the overall numbers of women affected are shown in Table 41.1 . These conditions are discussed later.

TABLE 41.1
Estimated Numbers and Incidence of the Major Global Causes of Direct Maternal Deaths and Severe Morbidity, 2000
Modified from AbouZahr C. Global burden of maternal death. In: British Medical Bulletin. Pregnancy: Reducing Maternal Death and Disability . British Council. Oxford University Press; 2003:1–13.
Cause Incidence of Complication (% of Live Births) Number of Cases Case Fatality Rate (%) Maternal Deaths % of All Direct Deaths
Hemorrhage 10.5 13,795,000 1.0 132,000 28
Sepsis 4.4 5,768,00 1.3 79,000 16
Preeclampsia, Eclampsia 3.2 4,152,000 1.7 63,000 13
Obstructed labor 4.6 6,038,000 0.7 42,000 9
Abortion 14.8 19,340,000 0.3 69,000 15

Babies Who Die

As stated earlier, approximately 2.7 million babies die in the first week of life, half on the day of their birth. In addition, another 2.6 million babies are stillborn. Approximately 80% of these newborn deaths are due to complications from prematurity, complications during labor and delivery, or infection, with similar complications especially during labor and delivery for those who are stillborn. Half of all babies who are stillborn are alive at the onset of labor. Most newborn deaths could be prevented if skilled health workers were available and performed effective interventions at birth and during the first week of life. However, not only are more skilled health professional workers required, but also deliveries should take place in a clean and well-equipped units with working transport links to more comprehensive facilities capable of managing emergency complications for both mother and baby.

You're Reading a Preview

Become a Clinical Tree membership for Full access and enjoy Unlimited articles

Become membership

If you are a member. Log in here