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Low-Grade Squamous Intraepithelial Lesion (Flat Condyloma/Cervical Intraepithelial Neoplasia I)
D efinition —An infection of the mature ectocervical and/or metaplastic cervical transformation zone epithelium by human papillomavirus (HPV).
Clinical Features
Epidemiology
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Most commonly seen in sexually active, reproductive-age women.
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Can be diagnosed in any age group.
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Flat low-grade squamous intraepithelial lesions (LSILs) can be caused by either low- or high-risk HPV subtypes. Approximately one-half of ectocervical/metaplastic (squamocolumnar [SC] junction–negative) lesions contain high-risk HPVs in contrast to nearly all SC junction–positive lesions.
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