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Low-Grade Invasive Serous Carcinoma of the Ovary
D efinition — An invasive low-grade serous carcinoma.
Clinical Features
Epidemiology
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The less common serous carcinoma. Predominates in the fourth to sixth decades of life, but can be seen at virtually any age.
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Can arise in a serous borderline tumor (SBT) or SBT with complex architecture (intraepithelial carcinoma).
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Associated with mutations in regulators of the MAPK pathway (KRAS, BRAF, ERBB2) in about two thirds of tumors.
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