Lobeline

General information

Lobeline is derived from the plant Lobelia inflata (Indian tobacco). It is both an agonist and an antagonist at nicotinic receptors, although it is not structurally related to nicotine [ ]. It inhibits nicotine- and amphetamine-induced dopamine release by interacting with the tetrabenazine-binding site on the monoamine transporter. It also inhibits dopamine re-uptake. It has been used in smoking cessation, but is ineffective [ ].

Nausea, vomiting, coughing, tremor, and dizziness have been noted with an average dose of lobeline. It can also cause nausea, sweating, and palpitation when inhaled from a cigarette.