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Lansoprazole
See also Proton pump inhibitors
General information
Lansoprazole is a proton pump inhibitor. Its adverse reactions profile has been reviewed based on premarketing clinical studies, and has to be regarded with the reservations appropriate to this type of material. In 4749 patients the most frequent adverse reactions were headache (4.7%), diarrhea (3.2%), abdominal pain (2.2%), pharyngitis (1.8%), and nausea (1.4%); some patients had upper respiratory complaints or suffered anxiety or depression, or myalgia [ ]. The adverse reactions profile appears to be closely similar to that of omeprazole.
Lansoprazole 15 and 30 mg/day were more effective than placebo, but not misoprostol 200 micrograms qds, for the prevention of NSAID-induced gastric ulcers in a multicenter, double-blind, placebo-controlled trial in 537 patients without Helicobacter pylori infection who were long-term users of NSAIDs [ ]. However, adverse reactions were significantly more frequent (31% versus less than 20%) and treatment adherence significantly less (71% versus more than 90%) in patients taking misoprostol. The most commonly reported adverse effects in all groups were diarrhea, abdominal pain, and nausea.
Organs and systems
Gastrointestinal
Two cases of collagenous colitis associated with lansoprazole have been reported, both in older women [ ]. Each developed profuse watery diarrhea within weeks of starting lansoprazole for upper digestive disorders. Colonoscopy was normal and biopsies showed the typical features of collagenous colitis. There was rapid clinical improvement when lansoprazole was switched to rabeprazole, and the histology was normal in follow-up biopsies.
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