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High-Grade Squamous Intraepithelial Lesion (Vulvar Intraepithelial Neoplasia III) With Confluent Papillary Growth


D efinition —A papillary exophytic squamous lesion similar in morphology to vulvar intraepithelial neoplasia (VIN) III but with risk of underlying invasion.

Clinical Features

Epidemiology

  • Identical to that of a classic or usual high-grade VIN. May be associated with an invasive carcinoma. Human papillomavirus (HPV) positive, usually HPV 16. Predominating in the fifth and sixth decades of age.

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