High-Grade Squamous Intraepithelial Lesion (Cervical Intraepithelial Neoplasia II and III)

D efinition and T erminology

• A precancerous lesion arising at the cervical squamocolumnar (SC) junction that displays near full-thickness atypia and variable maturation of the neoplastic epithelium.

• Should be associated always with high-risk human papillomaviruses (HPVs) and with HPV16 in 40% to 60% of cases depending on the cytologic presentation.