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High-Grade Serous Carcinoma, Classic Type
D efinition — A pelvic serous carcinoma with papillary architecture and high nuclear grade.
Clinical Features
Epidemiology
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Approximately 15% associated with BRCA1 or BRCA2 germline mutation.
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Predominant in the sixth and seventh decades of life.
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Approximately 1% of women will develop this malignancy in their lifetime.
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Associated with nulliparity and talc exposure.
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Approximately 40% to 50% associated with a detectable tubal intraepithelial carcinoma in the distal fallopian tube.
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