Hepatitis, Halothane

Multiple exposures to halothane is the most important risk factor.

Prior Hx of jaundice or fever after anesthesia.

Females more susceptible.

Obesity an important factor.

Age:

• Halothane hepatitis is rare in pts <10 y old (3% of all cases).

• Pts <30 y of age make up about 10% of all cases.

• Most cases occur in pts >40 y.

• In older pts, the disease is more devastating.

Genetics: There is a strong family linkage associated with halothane hepatitis.

Type or duration or extent of surgery is not a risk factor.

Hx of non-halothane-related liver disease is also not a risk factor.

Concerns arise with the induction of cytochrome P450 2E1 enzyme by alcohol, barbiturates, or isoniazid. Hepatitis is more severe if CYP450 2E1 was previously induced by other medications/substances.