Physical Address

304 North Cardinal St.
Dorchester Center, MA 02124

Gastrinoma


Acknowledgment

The authors would like to acknowledge Dr. Christine Piefer’s contribution to this text in the previous edition.

Risk

  • Occurs in about 0.1–3 cases per million, usually in pts aged 20–50 y; male/female predominance about equal.

  • 65–80% of gastrinomas are sporadic and have high (40–85%) malignant potential.

  • 20–35% of cases occur with MEN1, with low (7–12%) malignant potential.

  • Less than 0.1% of all PUD is caused by gastrinomas.

Perioperative Risks

  • Risks associated with PUD

  • Associated abnormalities of MEN1

  • Risks associated with metastatic disease (regional lymph nodes, liver, bone)

Worry About

  • Large gastric fluid volume

  • Esophageal reflux (common)

  • Lyte imbalance and volume depletion secondary to secretory diarrhea

  • Coagulopathy due to liver metastases/resection

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