Fazadinium

General information

Originally claimed, from animal experiments, to be of rapid onset, short duration, and free of important adverse effects and reactions, this non-depolarizing relaxant has been found to be less satisfactory in man. The usual doses are 0.5–0.75 mg/kg, although 1 mg/kg is sometimes advocated for fast intubation (within 1–2 minutes). The duration of action is similar in man to that of d -tubocurarine and pancuronium. Excretion is primarily in the urine (50–80%, mostly in the first 6 hours), although a biliary route has also been suggested. Metabolism occurs, probably to a minor extent, 1–3% being detected in the urine as inactive metabolites.

Organs and systems