Falls and Drop Attacks—Introduction

Falling in childhood is part of growing up and usually medically insignificant, unless a serious childhood illness contributes. With advancing age, the potential for injury and other complications increases, and falling eventually develops into a dangerous burden for the elderly and the neurologically impaired. Quality of life can be severely affected by associated morbidity, immobilization, fear of falling (FOF), and growing dependency. Despite improved understanding of falls and their prevention, they remain a leading public health problem. The 2014 Behavioral Risk Factor Surveillance System (BRFSS) estimated that more than a fourth of adults older than 65 years have fallen, resulting in 29 million annual falls, more than 7 million injuries, and 800,000 hospital admissions in the United States. The corresponding cost to Medicare alone exceeded $31 billion and $50 billion for all medical care ( , August 17). Fall-related injuries belong to the 20 most costly medical conditions.

Clinically, a large number of etiologies of falls have to be considered. A useful initial approach is to determine whether a patient has suffered a drop attack or an accidental fall. In this discussion the term drop attack describes a sudden fall occurring without a prodrome that may or may not be associated with loss of consciousness and cannot be prevented by assistive devices. In contrast, falls reflect an inability to remain upright during a postural challenge. Potential etiologies of drop attacks include cardiac, epileptic, vascular, sleep, and vestibular disorders, as well as congenital brain abnormalities and intracranial masses. In neurological practice, falling is most commonly associated with chronic disorders such as neuropathies, stroke, multiple sclerosis (MS), parkinsonism, and dementia. Affected patients have impaired control of stability and gait due to functional declines in neuromuscular, sensory, vestibulocerebellar, and cognitive systems. Finally, the elderly, with their inevitable infirmities and accumulating functional deficits, frequently fall. These associations permit a classification of falls and drop attacks, as presented in Box 3.1 .

BOX 3.1
Causes and Types of Falls and Drops

Drop Attacks

  • With loss of consciousness:

    • Syncope

    • Seizures

  • Without loss of consciousness:

    • Transient ischemic attacks:

      • Vertebrobasilar insufficiency

      • Anterior cerebral artery ischemia

    • Third ventricular and posterior fossa tumors

    • Chiari malformation

    • Otolithic crisis

      • Cataplexy

Falls

  • Neuromuscular disorders (neuropathy, radiculopathy, and myopathy)

  • Cerebral or cerebellar disorders

  • Cryptogenic falls in the middle-aged

  • Aging, neurodegeneration, and the neural substrate of gait and balance:

    • Fear of falling

    • Basal ganglia disorders:

      • Parkinson disease

      • Progressive supranuclear palsy and other parkinsonian syndromes

    • The aged state

As is true for most neurological presentations, the medical history is essential in establishing the likely etiology of a patient’s fall. Aside from gender, age, medications, and neurological conditions, which all affect fall risk, answers to the following questions should be sought:

  • What were the circumstances of the fall and has the patient fallen before?

  • Did the patient lose consciousness? If so, for how long?

  • Did lightheadedness, vertiginous sensations, or palpitations precede the event?

  • Is there a history of a seizure disorder, startle sensitivity, excessive daytime sleepiness, or falls precipitated by strong emotions?

  • Does the patient have headaches or migraine attacks associated with weakness?

  • Does the patient have vascular risk factors, and were there previous symptoms suggestive of transient ischemic attacks (TIAs)?

  • Are there symptoms of sensory loss, limb weakness, or stiffness?

  • Is there a history of visual impairment, hearing loss, vertigo, or tinnitus?

The neurological examination identifies predisposing functional deficits. However, in the case of drop attacks, the examination is often normal, posing a diagnostic challenge. In such patients, neuroimaging is necessary. Further workup is tailored to the clinical circumstance and may include vascular imaging, cardiac and autonomic studies, electroencephalogram (EEG), nocturnal polysomnography, and, rarely, genetic and metabolic testing when related conditions are suspected. Psychogenic disorders of station and gait need to be considered in patients who frequently experience near falls without injuries.

Drop Attacks With Loss of Consciousness

Syncope

The manifestations and causes of syncope are described in Chapter 2 . Severe ventricular arrhythmias and hypotension lead to cephalic ischemia and falling. With sudden-onset third-degree heart block (Stokes-Adams attack), the patient loses consciousness and falls without warning. Other causes of decreased cardiac output, such as brady-arrythmias or tachyarrhythmias, are believed to be associated with prodromal faintness. However, reliance on history to determine a cardiac etiology of a fall may be inadequate because elderly patients with sick sinus syndrome can be amnestic for presyncopal symptoms. When occurring in young athletes, exertional drop attacks indicate the presence of potentially life-threatening structural heart disease, including aortic stenosis or right ventricular dysplasia, among others. A large atrial myxoma can present in the same manner.

Cerebral hypoperfusion due to peripheral loss of vascular tone (orthostasis) is usually identifiable by a presyncopal syndrome of progressive lightheadedness, faintness, dimming of vision, and “rubbery”-feeling legs, but even in the context of positive tilt-table testing, up to 37% of patients report a clinically misleading symptom of true, “cardiogenic” vertigo ( ). Vertigo and downbeat nystagmus may also occur with asystole ( ).

Seizures

Epileptic drop attacks are caused by several mechanisms, including asymmetrical tonic contractions of limb and axial muscles, loss of tone of postural muscles (atonic seizures), and seizure-related cardiac arrhythmias. Video-EEG monitoring of epileptic patients with a history of falls permits characterization of the various motor phenomena that cause loss of posture. Pediatric epileptic encephalopathy syndromes (e.g., Lennox-Gastaut syndrome and Dravet syndrome, as well as the myoclonic epilepsies) frequently present as drop attacks. A tilt-table test should be considered in children and adolescents to avoid overdiagnosing epilepsy ( ). Epileptic drops in young patients with epileptic encephalopathy syndromes can be reduced with vagal nerve stimulation in some, as well as with clobazam, rufinamide ( ) and cannabidiol oil ( ). Medically refractory cases may show improved control of epileptic drops, as well as developmental gains after callosotomy ( ). Falling as a consequence of the tonic axial component of startle-induced seizures may be controllable with lamotrigine. Paradoxically, some antiseizure drugs can precipitate epileptic drop attacks, such as carbamazepine in Rolandic epilepsy. In patients with a history of stroke, falling may be falsely attributed to motor weakness rather than to new-onset seizures. Destabilizing extensor spasms of spasticity can also be difficult to distinguish from focal seizures.

Drop Attacks Without Loss of Consciousness

Transient Ischemic Attacks

Drop attacks secondary to TIAs are sudden falls occurring without warning or obvious explanation such as tripping. Loss of consciousness either does not occur or is only momentary; the sensorium and lower limb strength are intact immediately or shortly after the patient hits the ground. Between episodes the neurological examination should not reveal lower limb motor or sensory dysfunction. The vascular distributions for drop attacks from TIAs are the posterior circulation and the anterior cerebral arteries.

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