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Endometrial Intraepithelial Neoplasia (Atypical Hyperplasia)
D efinition — A premalignant clonal expansion of altered endometrial glands.
Clinical Features
Epidemiology
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Endometrial intraepithelial neoplasia (EIN) is relatively common and carries an increased risk of development of type 1 endometrial adenocarcinoma.
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Women with excess estrogen (whether exogenous or endogenous) are at increased risk.
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Because of the production of excess estrogens, obese women are at an increased risk.
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Patients with hereditary nonpolyposis colorectal cancer (HNPCC) (Lynch syndrome) and Cowden syndrome are at an increased risk.
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Patients taking tamoxifen are at an increased risk of the development of EIN.
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