Cortical Stromal Hyperplasia and Hyperthecosis


D efinition An expansion of the ovarian cortex and medulla by a benign proliferation of ovarian cortical stromal cells and associated luteinized cells. Cortical stromal hyperplasia (CSH) is a mild form seen at menopause; stromal hyperthecosis is a more pronounced variant associated with symptoms comparable to polycystic ovarian syndrome.

Clinical Features

Epidemiology

  • Seen in perimenopausal or postmenopausal women.

  • May less commonly be seen as part of the clinical spectrum of polycystic ovarian syndrome (PCOS).

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