Contraception


The untoward consequences of sexual activity, including unintended pregnancy (see Chapter 144 ) and sexually transmitted infections (STIs; Chapter 146 ), are experienced by adolescents at unacceptably high rates. Adolescents often do not seek reproductive healthcare until 6-12 mo after initiating sex; many will become pregnant and/or acquire an STI during this interval. Early and appropriate counseling and educational interventions with adolescents, including direct discussion of unwanted pregnancy and STI prevention, can decrease risky sexual behavior; adolescents who plan sexual initiation are 75% more likely to use contraception at sexual debut. Therefore, appropriate counseling and provision of contraception as warranted are a critical component in comprehensive healthcare for adolescents.

Contraceptive Effectiveness

To decrease rates of unintended pregnancy, the American Academy of Pediatrics (AAP) and American College of Obstetricians and Gynecologists (ACOG) recommend adolescents use the most effective forms of reversible contraception. Comparing typical effectiveness of contraceptive methods the chart illustrates a tiered system of contraceptive methods ranging from more effective to less effective methods ( Fig. 143.1 ). These tiers are categorized by typical-use failure rates , which reflect the effectiveness of a method for the average person who may not consistently use the method or may not always use the method correctly ( Table 143.1 ). For example, for oral contraceptive pills, the typical-use failure rate is 7%, whereas the perfect-use failure rate is <1%. Tier 1 methods, the most effective, include those with failure rates of <1 pregnancy per 100 women in a year of typical use, and reversible Tier 1 methods include intrauterine devices (IUDs) and implants. Tier 2 methods have failure rates of 4-7 pregnancies per 100 women in a year of typical use and include injectable contraception, oral contraceptive pills, contraceptive patch, and vaginal ring. Tier 3 methods have failure rates of >13 pregnancies per 100 women per year of typical use and include the male and female condom, the diaphragm, withdrawal, the sponge, fertility awareness–based methods, and spermicides.

Fig. 143.1, Effectiveness of contraceptive methods.

Table 143.1
Efficacy of Contraceptives
Adapted from The Medical Letter : Choice of contraceptives. Med Lett 57(1477):128, 2015.
METHOD FAILURE RATE * SOME ADVANTAGES SOME ADVERSE EFFECTS AND DISADVANTAGES
Typical Use Perfect Use
Implant Convenience; long-term contraception; no patient compliance required; rapid return of fertility after removal Irregular bleeding; removal complications
Nexplanon 0.1% 0.1%
Intrauterine devices (lUDs) Convenience; long-term contraception; no patient compliance required; rapid return of fertility after removal Rare uterine perforation; risk of infection with insertion; anemia
ParaGard T380A 0.8% 0.6% Effective for 10 yr; nonhormonal Irregular/heavy bleeding and dysmenorrhea
Mirena 0.1% 0.1% Decreased menstrual bleeding and dysmenorrheal Irregular bleeding in 1st 3-6 mo, followed by amenorrhea; ovarian cysts
Liletta 0.1% 0.1% Decreased menstrual bleeding and dysmenorrheal Irregular bleeding in 1st 3-6 mo; ovarian cysts
Kyleena 0.2% 0.2% Smaller T-frame and narrower insertion tube Irregular bleeding in 1st 3-6 mo; ovarian cysts; amenorrhea in 13% of users after 1 yr
Skyla 0.4% 0.3% Smaller T -frame and narrower insertion tube Irregular bleeding in 1st 3-6 mo; ovarian cysts; amenorrhea in only 6% of users after 1 yr
Sterilization
Female 0.5% 0.5% Long-term contraception; no patient compliance required Potential for surgical complications; regret among young women; reversal often not possible and expensive
Male 0.15% 0.1% Long-term contraception; no patient compliance required Pain at surgical site, regret among young men; reversal often not possible and expensive
Injectable Convenience; same as progestin-only oral contraceptives Delayed return to fertility, irregular bleeding and amenorrhea; weight gain; may decrease bone mineral density
Depo-Provera 4% 0.2%
Combination oral contraceptives 7% 0.3% Protection against ovarian and endometrial cancer, PID, and dysmenorrhea Increased rate of thromboembolism, stroke, and myocardial infarction in older smokers; nausea; headache; contraindicated with breastfeeding
Progestin-only oral contraceptives 7% 0.3% Protection against PID. iron-deficiency anemia, and dysmenorrhea; safe in breastfeeding women and those with cardiovascular risk Irregular, unpredictable bleeding; must take at same time every day
Transdermal Convenience of once-weekly application; same benefits as combination oral contraceptives Dysmenorrhea and breast discomfort may be more frequent than with oral contraceptives; application site reactions; detachment; increased estrogen exposure compared to oral contraceptives
Evra 7% 0.3%
Vaginal Excellent cycle control; rapid return to fertility after removal; convenience of once-monthly insertion Discomfort; vaginal discharge
NuvaRing 7% 0.3%
Diaphragm with spermicide 17% 16% Low cost; may reduce risk of cervical cancer High failure rate; cervical irritation; increased risk of urinary tract infection and toxic shock syndrome; some require fitting by healthcare professional; may be difficult to obtain; available only by prescription
Condom without spermicide
Female 21% 5% Protection against STIs; covers external genitalia; OTC High failure rate; difficult to insert; poor acceptability
Male 13% 2% Protection against STIs, OTC High failure rate; allergic reactions; poor acceptability; breakage possible
Withdrawal 20% 4% No drugs or devices High failure rate
Sponge 14-27% 9-20% OTC; low cost; no fitting required; provides 24 hr of protection High failure rate; contraindicated during menses; increased risk of toxic shock syndrome
Fertility awareness–based methods 15% - Low cost; no drugs or devices High failure rate; may be difficult to learn; requires relatively long periods of abstinence
Standard Days method 12% 5%
TwoDay method 14% 4%
Ovulation method 23% 3%
Symptothermal method 2% 0.4%
Spermicide alone 21% 16% OTC High failure rate; local irritation; must be reapplied with repeat intercourse; increased risk of HIV transmission
No method 85% 85% -
STIs, Sexually transmitted infections; PID, pelvic inflammatory disease; OTC, over the counter.

* Risk of unintended pregnancy during first year of use; data from Trussel J, et al: In Hatcher RA et al: Contraceptive technology. ed 21, New York, 2018, Ayer Company Publishers.

Contraceptive Use

Tara C. Jatlaoui
Yokabed Ermias
Lauren B. Zapata

Keywords

  • sexual activity

  • sexual debut

Sexual Activity

According to the Youth Risk Behavior Surveillance System 2015, 41.2% of U.S. high school students had ever had sexual intercourse and approximately one-third reported being currently sexually active.

Although U.S. teens and European teens have similar levels of sexual activity and ages of sexual debut , U.S. teens are less likely to use contraception and less likely to use the most effective methods. Teen pregnancy rates have been declining worldwide as a result of delayed initiation of sexual activity and increased contraceptive use. Despite declines, the United States still had the highest 2013 teen birthrate in the Western industrialized world, with 26.5 live births per 1,000 females aged 15-19 yr ( Fig. 143.2 ). This is almost 1.5 times higher than the 2013 teen birthrate in the United Kingdom, which has the highest rate in Western Europe, and almost 8 times higher than the teen birthrate in Switzerland, which has the lowest rate in Western Europe. In 2011, of the 574,000 teen pregnancies in the United States, 75% were unintended, indicating an unmet need for reliable, effective contraception that teens will correctly and consistently use.

Fig. 143.2, Teen birthrates in high-income countries, 2013.

Use of Contraception Among Teens

According to the National Survey of Family Growth, 2011–2013, virtually all sexually experienced teens have used some method of contraception in the past. The most commonly used method by teenage females is the condom , followed by withdrawal (both least effective methods) and then the pill (a moderately effective method). IUDs and implants, the most effective reversible methods, are only used by 4.3% of female contraceptive users age 15-19 yr. Use of contraception at first sex has greatly increased over the last 50 yr. As of 2010, the condom is the most common method used at first sex, reported by >75% of males and females. Factors associated with contraception use at first sex include increasing age among teens up to age 17 yr; time spent in college; and planning their sexual debut.

More than half of sexually experienced female teens are currently using the most effective reversible contraceptives or moderately effective contraceptive methods. U.S. teens' use of hormonal methods at last intercourse is less frequent compared to teens in other developed countries: 52% of U.S. teens, 56% of Swedish 18-19 yr olds, 67% of French 15-19 yr olds, 72% of British 16-19 yr olds, and 73% of Canadian 15-19 yr olds use hormonal methods. A higher likelihood of female current contraceptive use is associated with older age at sexual initiation, aspirations for higher academic achievement, acceptance of one's own sexual activity, and a positive attitude toward contraception. Despite the importance of dual protection to protect against both unwanted pregnancy and STIs, only 21.3% of sexually active female U.S. teens are using condoms in addition to another, more effective contraceptive method.

Bibliography

  • American Academy of Pediatrics Committee on Adolescence : Contraception for adolescents. Pediatrics 2014; 134: pp. e1244-e1256.
  • Centers for Disease Control and Prevention : Contraceptive methods available to patients of office-based physicians and title X clinics—United States, 2009–2010. MMWR 2011; 60: pp. 1-4.
  • Darroch JE, Singh SS, Frost JJ, et. al.: Differences in teenage pregnancy rates among five developed countries: the roles of sexual activity and contraceptive use. Fam Plann Perspect 2001; 33: pp. 244-250.
  • Durex Network : The face of global sex 2007. First sex: opportunity of a lifetime.2007.SSL InternationalCambridge, UK
  • Ethier KA, Kann L, McManus T: Sexual intercourse among high school students—29 states and United States overall, 2005–2015. MMWR 2018; 66: pp. 1393-1397.
  • Finer LB, Zolna MR: Declines in unintended pregnancy in the United States, 2008–2011. N Engl J Med 2016; 374: pp. 843-852.
  • Hatcher RANelson ALTrussell J et. al.Contraceptive technology.2018.Ayer Company PublishersNew York:
  • Kann L, McManus T, Harris WA, et. al., Centers for Disease Control and Prevention: Youth Risk Behavior Surveillance—United States, 2015. MMWR Surveill Summ 2016; 65: pp. 1-174.
  • Lindberg L, Santelli J, Desai S: Understanding the decline in adolescent fertility in the United States, 2007–2012. J Adolesc Health 2016; 59: pp. 577-583.
  • Martin JA, Hamilton BE, Osterman MJ, et. al.: Births: final data for 2013. Natl Vital Stat Rep 2015; 64: pp. 1-65.
  • Martinez GM, Abma JC: Sexual activity, contraceptive use, and childbearing of teenagers aged 15-19 in the United States, NSFG 2011–2013. NCHS Data Brief 2015; 209: pp. 1-8.
  • Santelli JS, Lindberg LD, Finer LB, et. al.: Explaining recent declines in adolescent pregnancy in the United States: the contribution of abstinence and improved contraceptive use. Am J Public Health 2007; 97: pp. 1541-1548.
  • Tyler CP, Whiteman MK, Kraft JM, et. al.: Dual use of condoms with other contraceptive methods among adolescents and young women in the United States. J Adolesc Health 2014; 54: pp. 169-175.
  • United Nations : UN Demographic Yearbook.2013. Table 10, United Nations Statistics Division
  • Wellings K, Palmer MJ, Geary RS: Changes in conceptions in women younger than 18 years and circumstances of young mothers in England in 2000–12: an observational study. Lancet 2016; 388: pp. 586-595.

Contraceptive Counseling

Tara C. Jatlaoui
Yokabed Ermias
Lauren B. Zapata

Keywords

  • counseling

  • effectiveness

  • typical-use failure rates

  • confidentiality

  • teen-friendly

The health screening interview during the adolescent preventive visit offers opportunities to identify and discuss unsafe sexual practices among all adolescents and to identify and reinforce safe sexual behaviors, including abstinence (see Chapter 137 ). Adolescents with medical conditions, either chronic or acute, are particularly vulnerable to having sexual and reproductive health omitted from their visits, although they have similar sexual health and contraceptive needs as healthy adolescents (see Chapter 734 ). Their comorbidities or concurrent medication use may make unintended pregnancy an increased health risk and may also reduce contraceptive options. The U.S. Medical Eligibility Criteria for Contraceptive Use outlines medical conditions associated with increased risk for adverse health events as a result of pregnancy and also provides recommendations for who can safely use specific contraceptive methods.

The goals of counseling with adolescents are to (1) understand adolescent experiences, preferences, perceptions, and misperceptions about pregnancy and use of contraceptives; (2) help adolescents put unprotected intercourse risk in a personal perspective; (3) educate adolescents about the various methods available using information that is medically accurate, balanced, and provided in a nonjudgmental manner; and (4) help adolescents choose a safe and effective method that can either be provided on site or be easily obtained through prescription or by referral. Counseling should include a review of all contraceptive methods available that the adolescent can use safely (see U.S. Medical Eligibility Criteria), starting with the most effective methods. Long-acting reversible contraception (IUDs and implants) is a safe and effective option for many adolescents, including those who have not been pregnant or given birth. The adolescent should be counseled about method effectiveness using typical-use failure rates. It is important to ask about use of withdrawal because 60% of female teens have used it for contraception and it has a typical-use failure rate of 20%. Abstinence should also be discussed as an option even if teens have engaged in sexual intercourse in the past. Situational abstinence may be the best option if they do not have another method available at a particular time.

Necessary concepts to address while discussing individual methods include how effective the method is, how long the method works, what behaviors are required for correct and consistent use, what side effects may be seen, any noncontraceptive benefits of the method (e.g., reduced menstrual bleeding, protection from STIs), and what signs or symptoms of complications should prompt a return visit. Reviewing common side effects allows teens to anticipate and cope with any changes with reassurance and may avoid method discontinuation. Weighing the possibility of certain side effects with the possibility of an unintended pregnancy may also help with the conversation. It is also important to address any specific misperceptions teens may have for certain contraceptives regarding side effects, effectiveness, or any other concept discussed.

Once an adolescent chooses a method, the provider and adolescent should discuss clear plans on correct and consistent use of the chosen method and strategies for appropriate follow-up ( Table 143.1 ). Providers should help the adolescent consider potential barriers to correct and consistent use (e.g., forgetting to take a pill daily) and develop strategies to deal with each barrier (e.g., use of reminder systems such as daily text messages or phone alarms). The provider should assess whether the teen understood the information discussed and may confirm by asking the teen to repeat back key concepts.

The U.S. Selected Practice Recommendations for Contraceptive Use provides guidance for providers regarding when to start contraception, how to be certain the woman is not pregnant at contraception initiation, and what examinations and tests are recommended before initiating contraception. Generally, women may start a contraceptive method other than an IUD at any time, and an IUD may be placed when a provider is reasonably certain that a woman is not pregnant. Most women do not require any exams or tests before initiating contraception. A pelvic examination is only required for placement of an IUD, unless otherwise indicated. STI screening is appropriate at IUD placement once sexual activity has begun, but most women do not require additional screening if they have been recently screened according to CDC sexually transmitted disease (STD) treatment guidelines. Gonorrhea and chlamydia screening using a self- or provider-collected vaginal swab or urine sample is recommended unless symptoms require a pelvic exam. IUD placement should not be delayed to receive screening results. ACOG guidelines recommend that the female teen should first visit a gynecologist between age 13 and 15 yr, unless necessary at an earlier age. This visit aims to establish rapport, educate the patient and parents or guardian on healthy sexual development, and provide routine preventive services. Cervical cancer screening is not recommended until age 21.

Providers should offer confidential services to adolescents and observe all relevant state laws and legal obligations (e.g., notification or reporting of sexual abuse). Chapter 137 discusses confidentiality and consent issues related to contraceptive management. Providers should also encourage adolescents to involve parents or guardians in their healthcare decisions, while giving parents clear information on their teen's right to confidentiality, privacy, and informed consent. All services should be provided in a youth-friendly manner, meaning that they are accessible, equitable, acceptable, appropriate, comprehensive, effective, and efficient. Resources are available that describe ways to ensure a teen-friendly reproductive health visit.

Bibliography

  • American Academy of Pediatrics Committee on Adolescence : Contraception for adolescents. Pediatrics 2014; 134: pp. e1244-e1256.
  • American Academy of Pediatrics Committee on Adolescence : Contraception for adolescents. Pediatrics 2014; 134: pp. e1257-e1281.
  • American College of Obstetricians and Gynecologists Committee on Gynecologic Practice : Well-woman visit. Obstet Gynecol 2012; 120: pp. 421-424.
  • Boulet SL, D'Angelo D, Morrow B, et. al.: Contraceptive use among nonpregnant and postpartum women at risk for unintended pregnancy, and female high school students, in the context of Zika preparedness—United States, 2011–2013 and 2015. MMWR 2016; 65: pp. 780-787.
  • Centers for Disease Control and Prevention : Reproductive health: teen pregnancy. https://www.cdc.gov/teenpregnancy/health-care-providers/teen-friendly-health-visit.htm
  • Curtis KM, Jatlaoui TC, Tepper NK, et. al.: U.S. Selected practice recommendations for contraceptive use, 2016. MMWR Recomm Rep 2016; 65: pp. 1-66.
  • Curtis KM, Tepper NK, Jatlaoui TC, et. al.: U.S. medical eligibility criteria for contraceptive use, 2016. MMWR Recomm Rep 2016; 65: pp. 1-103.
  • Gavin L, Pazol K: Update: Providing quality family planning services—recommendations from CDC and the U.S. Office of Population Affairs, 2015. MMWR 2016; 65: pp. 231-234.
  • Hatcher RANelson ALTrussell J et. al.Contraceptive technology.2018.Ayer Company PublishersNew York:
  • Kann L, McManus T, Harris WA, et. al., Centers for Disease Control and Prevention: Youth Risk Behavior Surveillance—United States, 2015. MMWR Surveill Summ 2016; 65: pp. 1-174.
  • McIntyre P: Adolescent friendly health services: an agenda for change.2002.World Health OrganizationGeneva
  • Kirby D: Reducing pregnancy and risky behaviour in teenagers. BMJ 2009; 339: pp. 116-117.
  • Potter J, Santelli JS: Contraceptive counseling for adolescents. Womens Health 2015; 11: pp. 737-741.
  • The Medical Letter : Choice of contraceptives. Med Lett 2015; 57: pp. 127-132.
  • Romero L, Pazol K, Warner L, et. al.: Vital signs: trends in use of long-acting reversible contraception among teens aged 15-19 years seeking contraceptive services—United States, 2005–2013. MMWR 2015; 64: pp. 363-369.
  • Tepper NK, Krashin JW, Curtis KM, et. al.: Update to CDC's U.S. medical eligibility criteria for contraceptive use 2016: revised recommendations for the use of hormonal contraception among women at high risk for HIV infection. MMWR 2017; 66: pp. 990-994.
  • Tyler CP, Whiteman MK, Kraft JM, et. al.: Dual use of condoms with other contraceptive methods among adolescents and young women in the United States. J Adolesc Health 2014; 54: pp. 169-175.
  • Workowski KA, Bolan GA: Sexually transmitted diseases treatment guidelines, 2015. MMWR 2015; 64:

Long-Acting Reversible Contraception

Tara C. Jatlaoui
Yokabed Ermias
Lauren B. Zapata

Keywords

  • LARC

  • intrauterine devices

  • implants

Long-acting reversible contraception ( LARC ) includes 4 levonorgestrel (LNG) IUDs, the copper (Cu) IUD, and the etonogestrel subdermal implant. LARC methods are the only Tier 1 methods that are reversible (see Fig. 143.1 ). Considered “forgettable” contraception, LARC does not require frequent office or pharmacy visits and does not depend on user compliance for effectiveness. In the Contraceptive CHOICE Project in St. Louis, MO, >9,000 women were given the contraceptive method of their choice at no cost and were followed for 2-3 yr. The failure rates among women who used oral contraceptive pills, transdermal patch, or vaginal ring were >20 times higher than the failure rates for women using a LARC method. Acceptance, continuation, and satisfaction in this project were also higher among adolescents using LARC compared with adolescents using non-LARC methods. ACOG and AAP support the use of LARC methods for adolescents. The U.S. Medical Eligibility Criteria supports safe use of both IUDs and implants for adolescents and nulliparous women. Implants are considered category 1 for all ages, and IUDs are considered category 2 for women <20 yr old and for nulliparous women ( Table 143.2 ).

Table 143.2
Categories of Medical Eligibility Criteria for Contraceptive Use

  • Category 1 : A condition for which there is no restriction for the use of the contraceptive method.

  • Category 2 : A condition for which the advantages of using the method generally outweigh the theoretical or proven risks.

  • Category 3 : A condition for which the theoretical or proven risks usually outweigh the advantages of using the method.

  • Category 4 : A condition that represents an unacceptable health risk if the contraceptive method is used.

Intrauterine Devices

IUDs are small, flexible, plastic objects introduced into the uterine cavity through the cervix. They differ in size, shape, and the presence or absence of pharmacologically active substances. In the United States, 5 IUDs are currently approved by the Food and Drug Administration (FDA): the CuT380A (Paragard) and 4 LNG IUDs (Liletta, Kyleena, Mirena, and Skyla). The effectiveness of the Cu IUD is enhanced by the copper ions released into the uterine cavity, with possible mechanisms including inhibition of sperm transport and prevention of implantation; this IUD is effective for at least 10 yr.

The LNG IUDs also have various actions, from thickening of cervical mucus and inhibiting sperm survival to suppressing the endometrium. LNG IUDs are effective for at least 3 and 5 years. All IUDs have typical-use failure rates of <1% (see Fig. 143.1 ).

Common misconceptions of IUDs among healthcare providers are that IUDs cause infections, infertility, and generally are not safe for teens or nulliparous women to use; these misconceptions are a barrier to teens accessing these highly effective and acceptable methods. IUDs do not increase risk of infertility and may be inserted safely in teens as well as nulliparous women (category 2; see Table 143.2 ).

Although early studies suggested an increased risk for upper genital tract infection, theoretically as a result of passing a foreign body through the cervix, newer work has refuted these earlier concerns. Therefore, clinicians are encouraged to consider use of IUDs in adolescents despite relatively high prevalence rates of STIs in this population. Teens should be screened for gonorrhea and chlamydia at or before IUD placement, although placement should not be delayed if results have not returned and there are no signs of current infection (e.g., purulent discharge, erythematous cervix). If STI testing is positive with an IUD in place, the patient may be treated without removing the IUD if she wants to continue the method. Evidence from 2 systematic reviews did not find benefit in routinely administering misoprostol to women undergoing routine IUD placement to decrease pain or improve provider ease of insertion. A paracervical block with lidocaine may reduce patient discomfort during placement and, along with other medications (e.g., NSAIDs, anxiolytics), may be considered on an individual patient basis, but these are not routinely recommended.

Implants

Currently, one contraceptive implant is available in the United States. Originally FDA approved in 2006, the single rod that releases 60 µg/day of etonogestrel has been updated to a radiopaque rod with a new inserter. This progestin-only method keeps etonogestrel at steady serum levels for at least 3 yr and primarily works to inhibit ovulation. Similar to the levonorgestrel IUD, the progestin acts on the uterus to cause an atrophic endometrium and thicken cervical mucus to block sperm penetration; its typical-use failure rate is also <1% (see Fig. 143.1 ). Unlike the IUD, no pelvic exam is required for insertion. A trained provider can quickly place or remove the implant in the upper arm under local anesthesia. Common side effects include amenorrhea, irregular bleeding, or infrequent bleeding, and less often, prolonged or frequent bleeding. One potential unique complication of this method relates to localized infection and other side effects after implantation, such as bleeding, hematoma, or scarring, and if inserted too deeply into the muscle, neural damage or migration; however, these events are rare, occurring in <1% of patients. Minor side effects, such as bruising or skin irritation, are more common but most often resolve without treatment.

Bibliography

  • American Academy of Pediatrics Committee on Adolescence : Contraception for adolescents. Pediatrics 2014; 134: pp. e1244-e1256.
  • American College of Obstetricians and Gynecologists Committee on Gynecologic Practice : Adolescents and long-acting reversible contraception: implants and intrauterine devices. ACOG Committee Opinion No. 735. American College of Obstetricians and Gynecologists. Obstet Gynecol 2018; 131: pp. e130-e139.
  • Curtis KM, Tepper NK, Jatlaoui TC, et. al.: U.S. medical eligibility criteria for contraceptive use, 2016. MMWR Recomm Rep 2016; 65: pp. 1-103.
  • Curtis KM, Jatlaoui TC, Tepper NK, et. al.: U.S. selected practice recommendations for contraceptive use, 2016. MMWR Recomm Rep 2016; 65: pp. 1-66.
  • Curtis KM, Peipert JF: Long-acting reversible contraception. N Engl J Med 2017; 376: pp. 461-468.
  • Hatcher RANelson ALTrussell J et. al.Contraceptive technology.2018.Ayer Company PublishersNew York:
  • The Medical Letter : Liletta—a third levonorgestrel-releasing IUD. Med Lett 2015; 57: pp. 99-100.
  • The Medical Letter : Kyleena—another hormonal IUD. Med Lett 2017; 59: pp. 38-40.
  • Mestad R, Secura G, Allsworth JE, et. al.: Acceptance of long-acting reversible contraceptive methods by adolescent participants in the Contraceptive CHOICE Project. Contraception 2011; 84: pp. 493-498.
  • Peipert JF, Zhao Q, Allsworth JE, et. al.: Continuation and satisfaction of reversible contraception. Obstet Gynecol 2011; 117: pp. 1105-1113.
  • Peterson HB, Curtis KM: Long-acting methods of contraception. N Engl J Med 2005; 353: pp. 2169-2175.
  • Rosenstock JR, Peipert JF, Madden T, et. al.: Continuation of reversible contraception in teenagers and young women. Obstet Gynecol 2012; 120: pp. 1298-1305.
  • Secura GM, Allsworth JE, Madden T, et. al.: The Contraceptive CHOICE Project: reducing barriers to long-acting reversible contraception. Am J Obstet Gynecol 2010; 203: pp. 115.e1-115.e7.
  • Winner B, Peipert JF, Zhao Q, et. al.: Effectiveness of long-acting reversible contraception. N Engl J Med 2012; 366: pp. 1998-2007.

Other Progestin-Only Methods

Tara C. Jatlaoui
Yokabed Ermias
Lauren B. Zapata

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