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Cloacogenic Neoplasia
D efinition —“Ectopic,” colonic-type neoplasia (adenoma/carcinoma) arising in the vaginal or vulvar mucosa.
Clinical Features
Epidemiology
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Origin is in colonic-type epithelium, presumably incorporated into the vaginal or vulvar region following formation of the urorectal septum in early development.
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Another possible scenario is intestinal metaplasia of vaginal adenosis as rare cases have been reported in diethylstilbestrol (DES)–exposed women.
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Typically seen in adults, implying an age-related transformation of colonic-type epithelium to form these neoplasms.
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