Plasma Cell Neoplasms Definition The plasma cell neoplasms and related disorders are clonal proliferations of immunoglobulin (Ig)-producing plasma cells or lymphocytes that make and secrete a single class of Ig or a polypeptide subunit of a single Ig that is…
This chapter reviews two aggressive large B-cell lymphomas composed of large cells with a predominant immunoblastic or plasmablastic morphology and the immunophenotype of plasma cells. Despite sharing these morphologic and immunophenotypical features, one of them, plasmablastic lymphoma (PBL), occurs in…
Burkitt's Lymphoma Denis Burkitt is credited with the pioneering work that led in 1958 to the first description of the clinical features of this unique tumor, the delineation of its geographic distribution, and the introduction of novel treatment protocols with…
Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma. In contrast to indolent (low-grade) lymphoma, the survival curve typically shows an initial downward slope followed by a plateau, indicating the potential curability of a significant proportion of patients who achieve…
Definition In the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, the World Health Organization defines mantle cell lymphoma (MCL) as a mature B-cell neoplasm generally composed of monomorphic small to medium-sized lymphoid cells with irregular nuclei that carries…
Definition Nodal marginal zone lymphoma (NMZL) is a primary nodal B-cell neoplasm derived from post–germinal center B cells. This lymphoma shares morphologic and immunophenotypic similarities with other marginal zone lymphomas, particularly extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue…
Primary cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of B-cell lymphomas that present in the skin without evidence of extracutaneous disease at the time of diagnosis. CBCLs are much less common than primary cutaneous T-cell lymphomas (CTCLs). In Western…
In classifying non-Hodgkin's lymphomas, considerable attention has been paid to architectural, cytologic, and functional similarities among the various lymphomas and normal lymphoid tissue, exemplified by the peripheral lymph node. However, studies of extranodal lymphomas, particularly gastrointestinal lymphomas (accounting for the…
Definition Follicular lymphoma (FL) is defined in fourth edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues as a neoplasm composed of follicle center (germinal center) B cells (typically both centrocytes and centroblasts) that usually has at…
Definition The term splenic marginal-zone lymphoma (SMZL) was coined by Schmid and colleagues in 1992 for a B-cell lymphoma involving the spleen and bone marrow characterized by a micronodular tumoral infiltration that replaces the preexisting lymphoid follicles and shows marginal-zone…